2. Immunology/Inflammation
  3. Osteopontin
  4. Anti-Mouse osteopontin/SPP1 Antibody (100D3)

Anti-Mouse osteopontin/SPP1 Antibody (100D3) 

目录号: HY-P990795
技术支持

Anti-Mouse osteopontin/SPP1 Antibody (100D3) 是一种抗小鼠的 osteopontin/SPP1 IgG2c 单克隆抗体。Anti-Mouse osteopontin/SPP1 Antibody (100D3) 可以逆转骨桥蛋白 (OPN) 对 T 细胞的抑制作用，增强细胞毒性 T 淋巴细胞 (CTL) 的杀伤能力。Anti-Mouse osteopontin/SPP1 Antibody (100D3) 可以提高牙本质密度。Anti-Mouse osteopontin/SPP1 Antibody (100D3) 可用于研究癌症和牙齿相关疾病，如结肠癌。Anti-Mouse osteopontin/SPP1 Antibody (100D3) 的同型对照为 Mouse IgG2c kappa, Isotype Control (HY-P99981)。

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Anti-Mouse osteopontin/SPP1 Antibody (100D3)

Anti-Mouse osteopontin/SPP1 Antibody (100D3) Chemical Structure

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Anti-Mouse osteopontin/SPP1 Antibody (100D3) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse osteopontin/SPP1 Antibody (100D3) is an anti-mouse osteopontin/SPP1 IgG2c monoclonal antibody. Anti-Mouse osteopontin/SPP1 Antibody (100D3) can reverse the inhibition of osteopontin (OPN) on T cells and enhance cytotoxic T lymphocyte (CTL) killing ability. Anti-Mouse osteopontin/SPP1 Antibody (100D3) can improve dentin density. Anti-Mouse osteopontin/SPP1 Antibody (100D3) can be used for researches on cancer and dental related conditions such as colon cancer. The recommend isotype control of Anti-Mouse osteopontin/SPP1 Antibody (100D3): Mouse IgG2c kappa, Isotype Control (HY-P99981)[1][2].

同型

Mouse IgG2c kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

osteopontin/SPP1
体外研究
(In Vitro)

Anti-Mouse osteopontin/SPP1 Antibody (100D3) (3 天) 可以逆转骨桥蛋白 (OPN) 对 T 细胞增殖的抑制作用[1]。
Anti-Mouse osteopontin/SPP1 Antibody (100D3) (24 小时) 显著提高了细胞毒性 T 淋巴细胞 (CTL) 对 CT26 的杀伤效率[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse osteopontin/SPP1 Antibody (100D3) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse osteopontin/SPP1 Antibody (100D3) (200 μg，皮下注射，每 3 天一次，持续 14 天) 显著减少了携带 CT26 肿瘤的 Balb/c 小鼠的肺转移结节[1]。
Anti-Mouse osteopontin/SPP1 Antibody (100D3) (200 μg，皮下注射，每周两次，从第 7 天到第 60 天) 有效地改善了 BALB/c 小鼠的牙本质密度[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 2×105 CT26 cells injected Balb/c mice (2-3 months)[1]
Dosage: 200 μg
Administration: Subcutaneous injection (s.c.), once every 3 days, for 14 days
Result: Significantly reduced the number of lung metastatic nodules.
Animal Model: BALB/C mice (6 weeks)[2]
Dosage: 200 μg
Administration: Subcutaneous injection (s.c.), twice a week, from day 7 to day 60
Result: Significantly increased the dentin density of the second and third molars.
Had no significant improvement in alveolar bone volume, density, and thickness.
Decreased serum FGF23 levels, but blood phosphorus levels did not return to normal.
基因 ID

20750  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-Mouse osteopontin/SPP1 Antibody (100D3) 相关分类

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse osteopontin/SPP1 Antibody (100D3)OsteopontinSecreted Phosphoprotein 1osteopontin/SPP1T cellOPNCTLtoothCT26Inhibitorinhibitorinhibit

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