2. Apoptosis
  3. c-Myc
  4. Anticancer agent 84

Anticancer agent 84 是抗癌剂。Anticancer agent 84 通过稳定 G-四链体 (G4) 结构来抑制 c-MYC 的转录。Anticancer agent 84 可用于癌症研究。

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Anticancer agent 84 Chemical Structure

Anticancer agent 84 Chemical Structure

CAS No. : 2714510-72-0

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Anticancer agent 84 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 84 is an anticancer agent. Anticancer agent 84 represses the transcription of c-MYC by stabilizing the G-quadruplex (G4) structure. Anticancer agent 84 can be used for the research of cancer[1].

IC50 & Target

IC50: 5.0 μM (HepG2); 3.9 μM (MDA-MB-231); ＞100 μM (HBL-100)[1]
体外研究
(In Vitro)

Anticancer agent 84 has cytotoxicity in cancer cells (HepG2, MDA-MB-231) and normal cells (HBL-100) with IC50 values of 5.0 μM, 3.9 μM and ＞100 μM, respectively[1].
Anticancer agent 84 displays good c-MYC G4 binding and stabilization abilities[1].
Anticancer agent 84 blocks c-MYC transcription by targeting the promoter G4, leading to c-MYC-dependent cancer cell death in triple-negative breast cancer cell MDA-MB-23[1].
Anticancer agent 84 (2 μM) significantly disrupts the binding of the three proteins (NM23-H2, BLM and DHX36) to c-MYC G4 with IC50 values of 0.16 μM, 2.3 μM and 7.0 μM, respectively[1].
Anticancer agent 84 (0-5 μM) impacts c-MYC-related events in TNBC, including proliferation, invasion, cell cycle, and apoptosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 84 相关抗体:

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 1.25, 2.5, 5 μM
Incubation Time: 48 h
Result: Decreased the mRNA levels of c-MYC.

Cell Cycle Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 1.25, 2.5, 5 μM
Incubation Time: 24 h
Result: Could arrest MDA-MB-231 cells at the Sub G0 phase.

Apoptosis Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 1.25, 2.5, 5 μM
Incubation Time: 24 h
Result: Induced early apoptosis and necrosis in MDA-MB-231 cells.

RT-PCR[1]

Cell Line: MDA-MB-231 cells
Concentration: 1.25, 2.5 μM
Incubation Time: 24 h
Result: Exhibited relatively weak effects on other genes and suppressed c-MYC transcription by targeting c-MYC G4.

Cell Cytotoxicity Assay[1]

Cell Line: MDA-MB-231 cells
Concentration:
Incubation Time: 48 h
Result: Displayed good cytotoxicity against various cancer cells, including MDA-MB-231, MCF-7, HepG2, and SiHa and displayed less cytotoxicity against normal HBL-100 and NCM460 cells.

Cell Proliferation Assay[1]

Cell Line: MDA-MB-231 cells
Concentration: 1.25, 2.5, 5 μM
Incubation Time: 10 days
Result: Exhibits good antiproliferative activity.

Cell Invasion Assay[1]

Cell Line: MDA-MB-231 cells
Concentration: 1.25, 2.5, 5 μM
Incubation Time: 24 h
Result: Obviously decreased the invasion with an IC50 value of 1.7 μM.
体内研究
(In Vivo)

Anticancer agent 84 (i.p.; 2.5 mg/kg; daily; for 24 days) significantly inhibits tumor growth in the MDAMB-231 mouse xenograft model accompanied by c-MYC downregulation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/C-nu/nu mice(female, five-week-aged, 10−12 g)[1]
Dosage: 2.5 mg/kg
Administration: intraperitoneally, daily, for 24 days
Result: Exhibited potent antitumor activity and could act as a c-MYC repressor in vivo.
分子量

994.18

Formula

C57H67N7O9
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 84 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 842714510-72-0Anticancer agent84Anticancer agent-84c-MycMycanticancerc-MYCG-quadruplex (G4)cancerHepG2 cellsMDA-MB-231 cellsInhibitorinhibitorinhibit

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