2. Anti-infection Neuronal Signaling MAPK/ERK Pathway
  3. Fungal Calcineurin p38 MAPK
  4. Antifungal agent 18

Antifungal agent 18 是一种抗真菌剂，对主要的人类真菌病原体具有广谱抗真菌活性。Antifungal agent 18 通过靶向未折叠蛋白反应 (UPR) 、钙调磷酸酶 (calcineurin) 和 MAPK 通路来破坏真菌细胞壁的完整性。Antifungal agent 18 在体内外均表现出抗真菌活性。Antifungal agent 18 可用于侵袭性真菌病原体和皮肤癣菌的研究。

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Antifungal agent 18

Antifungal agent 18 Chemical Structure

CAS No. : 2572713-30-3

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10 mg ￥1215
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Antifungal agent 18 相关抗体

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antifungal agent 18 is an antifungal agent. Antifungal agent 18 shows a broad-spectrum antifungal activity against major human fungal pathogens. Antifungal agent 18 compromises fungal cell wall integrity by targeting the unfolded protein response (UPR), calcineurin, and MAPK pathways. Antifungal agent 18 shows antifungal activity in virto and vivo. Antifungal agent 18 can be used for the research of invasive fungal pathogens and cutaneous dermatophytes[1].

体外研究
(In Vitro)

Antifungal agent 18 (compound 22h) (0.5-128 μg/mL) 对新型念珠菌 (H99)、白色念珠菌 (SC5314)、光滑念珠菌 (BG2) 和烟曲霉 (af293) 均表现出抗真菌活性，MIC 分别为 1、2、4 和 4 μg/mL[1]。
Antifungal agent 18 (0.5-12.5 μM，24 小时) 在 HEK293T 和 HaCaT 细胞中无显著细胞毒性[1]。
Antifungal agent 18 (0-32 μg/mL，24 小时) 是一种快速起效的杀菌药物，可对抗引起侵袭性或皮肤感染的多种人类真菌病原体[1]。
Antifungal agent 18 (40 天) 不会诱导白色念珠菌和光滑念珠菌产生耐药性[1]。
Antifungal agent 18 (0-8 μg/mL，24 小时) 会破坏新型念珠菌的细胞形态，降低细胞壁和荚膜厚度，并导致白色念珠菌的细胞质与细胞膜分离[1]。
Antifungal agent 18 (0-8 μg/mL，0-2 小时) 可激活 Mpk1 通路，并提高 HXL1 活化水平，从而激活 UPR 通路[1]。
Antifungal agent 18 (8 μg/mL，90 分钟) 可诱导 Crz1 核转位，从而激活钙调磷酸酶通路[1]。
Antifungal agent 18 (0.1%-5% w/w，24 小时) 在红色毛癣菌感染的指甲模型中表现出优异的抗真菌活性，且呈浓度依赖性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antifungal agent 18 相关抗体:

Western Blot Analysis[1]

Cell Line: C.neoformans WT cells and C.neoformans H99 cells
Concentration: 4 and 8 μg/mL
Incubation Time: 30, 60, 90 min, and 2 h
Result: Increased pMpk1 levels within 30 min, which peaked at 60 min and decreased after 90 min.
Increased the ratio of HXL1s/HXL1u in a dose-dependent manner.
体内研究
(In Vivo)

Antifungal agent 18 (2% w/w，表皮涂抹，6、24 和 48 小时) 在白色念珠菌感染小鼠模型中显示出抗真菌活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c mice (7-week-old) subcutaneously injected with C.albicans cells[1]
Dosage: 2 % w/w
Administration: topical application., 6, 24, and 48 h
Result: Resulted in a marked reduction in the size of inflammation.
Resulted in a relatively softer epidermal stratum corneum and a more compact epidermal keratin layer compared to the vehicle group.
分子量

401.76

Formula

C19H23Cl3N2O
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

Antifungal agent 18 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antifungal agent 182572713-30-3Antifungal agent18Antifungal agent-18FungalCalcineurinp38 MAPKPP2BPPP3antifungalbroad-spectrumcell wall integrityUPRcalcineurinMpk1MAPKinvasive fungal pathogenscutaneous dermatophytesC.neoformansC.albicansC.glabrataA.fumigatusT.rubrum-infected nail modelC.albicans Infection modelInhibitorinhibitorinhibit

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