2. Cell Cycle/DNA Damage Protein Tyrosine Kinase/RTK Cytoskeleton
  3. FLT3 Microtubule/Tubulin Bcr-Abl
  4. Antiproliferative agent-30

Antiproliferative agent-30 (Compound 8g) 抑制微管蛋白组装并抑制 FLT3 和 Abl1。Antiproliferative agent-30 具有血管破坏活性。Antiproliferative agent-30 对癌细胞系具有广泛的抗增殖活性 (对于 HCT-116、K562、MV-4-11 细胞 的 IC50 分别为 0.054 nM、0.008 nM、0.144 nM)。Antiproliferative agent-30 对FLT3-ITD-TKD突变的 AML 也具有抗癌作用。

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Antiproliferative agent-30

Antiproliferative agent-30 Chemical Structure

CAS No. : 2713553-88-7

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Antiproliferative agent-30 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antiproliferative agent-30 (Compound 8g) inhibits tubulin assembly and inhibits FLT3 and Abl1. Antiproliferative agent-30 has vascular-disrupting activity. Antiproliferative agent-30 has broad antiproliferative activities against cancer cell lines (IC50s: 0.054 nM, 0.008 nM, 0.144 nM for HCT-116, K562, MV-4-11 cells respectively). Antiproliferative agent-30 also has anticancer effect against AML with FLT3-ITD-TKD mutation[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
0.169 nM
Compound: 8g
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
[PMID: 37544183]
A549/TR IC50
168 nM
Compound: 8g
Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
[PMID: 37544183]
HCT-116 IC50
0.054 nM
Compound: 8g
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
[PMID: 37544183]
HT-29 IC50
7.985 nM
Compound: 8g
Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
[PMID: 37544183]
K562 IC50
0.008 nM
Compound: 8g
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
[PMID: 37544183]
K562/Adr IC50
693 nM
Compound: 8g
Antiproliferative activity against human K562/Adr cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human K562/Adr cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
[PMID: 37544183]
MCF7 IC50
123.777 nM
Compound: 8g
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
[PMID: 37544183]
MDA-MB-231 IC50
25.137 nM
Compound: 8g
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
[PMID: 37544183]
MOLT-4 IC50
6.794 nM
Compound: 8g
Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
[PMID: 37544183]
MV4-11 IC50
0.144 nM
Compound: 8g
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
[PMID: 37544183]
MV4-11 IC50
0.144 nM
Compound: 8g
Antiproliferative activity against human MV4-11 cells transfected with FLT3-ITD mutant assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human MV4-11 cells transfected with FLT3-ITD mutant assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
[PMID: 37544183]
PANC-1 IC50
224.867 nM
Compound: 8g
Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
[PMID: 37544183]
PLC-PRF-5 IC50
21.553 nM
Compound: 8g
Antiproliferative activity against human PLC-PRF-5 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human PLC-PRF-5 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
[PMID: 37544183]
THP-1 IC50
77.953 nM
Compound: 8g
Antiproliferative activity against human THP-1 cells transfected with wild type FLT3 assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human THP-1 cells transfected with wild type FLT3 assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
[PMID: 37544183]
分子量

434.49

Formula

C24H26N4O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antiproliferative agent-30 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antiproliferative agent-302713553-88-7Antiproliferative agent30Antiproliferative agent 30FLT3Microtubule/TubulinBcr-AblCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3AnticancerAMLvascular-disruptingantiproliferativeHCT-116K562MV-4-11Inhibitorinhibitorinhibit

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