2. Stem Cell/Wnt TGF-beta/Smad
  3. TGF-beta/Smad
  4. Apitegromab

Apitegromab  (Synonyms: 阿匹特古单抗; SRK-015)

目录号: HY-P99441 纯度: 99.51%
COA 技术支持

Apitegromab (SRK-015) 是一种抗肌生长抑制素单克隆抗体。Apitegromab 可用于包括脊髓性肌萎缩症在内的神经肌肉疾病的研究。

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CAS No. : 2278276-46-1

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5 mg ￥6000
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Apitegromab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Apitegromab (SRK-015) is an anti-promyostatin monoclonal antibody. Apitegromab can be used for the research of neuromuscular disease including spinal muscular atrophy[1][2].

同型

Human IgG4 lambda
种属

Human
体外研究
(In Vitro)

Apitegromab (IC50：人 286 nM，食蟹猴 626 nM，大鼠 178 nM，16 小时) 有效抑制促肌肉生长抑制素的活化，并表现出物种依赖性的效力差异[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apitegromab 相关抗体:
药代动力学
(Parmacokinetics)[2]
Species Dose SampleTime Route Indicator value
Cynomolgus Monkey 10 mg/kg 1 day i.v. Cmax 369 μg/mL
Cynomolgus Monkey 100 mg/kg 1 day i.v. Cmax 2560 μg/mL
Cynomolgus Monkey 30 mg/kg 1 day i.v. Cmax 876 μg/mL
Rat 10 mg/kg 1 day i.v. AUC0-t 16200 μg·h/mL
Rat 10 mg/kg 1 day i.v. Cmax 213 μg/mL
Rat 100 mg/kg 1 day i.v. AUC0-t 170000 μg·h/mL
Rat 30 mg/kg 1 day i.v. AUC0-∞ 51100 μg·h/mL
Cynomolgus Monkey 10 mg/kg 1 day i.v. Tmax 1 hr
Cynomolgus Monkey 100 mg/kg 1 day i.v. Tmax 1 hr
Cynomolgus Monkey 30 mg/kg 1 day i.v. Tmax 1 hr
Rat 100 mg/kg 1 day i.v. Cmax 2360 μg/mL
Rat 30 mg/kg 1 day i.v. Cmax 695 μg/mL
Cynomolgus Monkey 10 mg/kg 1 day i.v. AUC0-t 30400 μg·h/mL
Cynomolgus Monkey 100 mg/kg 1 day i.v. AUC0-t 240000 μg·h/mL
Cynomolgus Monkey 30 mg/kg 1 day i.v. AUC0-t 77200 μg·h/mL
Rat 10 mg/kg 1 day i.v. Tmax 1.0 hr
Rat 100 mg/kg 1 day i.v. Tmax 1 hr
Rat 30 mg/kg 1 day i.v. Tmax 1 hr
体内研究
(In Vivo)

Apitegromab (10-300 mg/kg, 静脉注射，一周一次，共 4、7 或 26 周) 在幼年和成年 Sprague Dawley 大鼠以及成年食蟹猴中耐受性良好，未见严重毒性反应[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult cynomolgus monkeys (32-48 months)[2]
Dosage: 10, 30, 100 mg/kg
Administration: Intravenous bolus (IV bolus), once weekly for 4 weeks
Result: Did not cause treatment-related adverse effects, increased gastrocnemius and biceps brachii mass (5-25%), but did not exhibit dose dependency, and did not lead to significant histopathological changes or cardiac electrophysiological abnormalities.
Animal Model: Sprague Dawley rats: adult group (6-8 weeks) or juvenile group (postnatal day 21)[2]
Dosage: 10, 30, 100, 300 mg/kg
Administration: Intravenous bolus (IV bolus), once weekly for 4 weeks (adult group), 7 weeks (juvenile group) or 26 weeks (adult group)
Result: Increased body weight independently of food intake, enhanced skeletal muscle mass (biceps brachii and gastrocnemius) by 3-32%, and caused minor clinical chemistry changes (mild increase in total protein and globulin), which were mostly reversible (adult group, administration for 4 weeks).
increased muscle mass by 15-33%, induced mild muscle fiber hypertrophy (histological analysis), and caused minor hematological changes without significant toxicity; it did not produce adverse effects on cardiovascular, neurological, or reproductive systems (adult group, administration for 26 weeks).
increased body weight (significant in females) without impacting growth and development, enhanced skeletal muscle mass (biceps brachii and gastrocnemius) by 13-28%, and did not cause neurobehavioral abnormalities (acoustic startle, locomotor activity, Morris water maze); it had no effects on sperm quality or fertility, indicating normal reproductive function (juvenile group).
Clinical Trial
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

145.06 kDa

同用名

阿匹特古单抗; SRK-015

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

阿匹特古单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 lambda
纯度 & 产品资料

纯度: 99.51%

COA (266 KB) SDS-PAGE (80 KB) SEC-HPLC (168 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Apitegromab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apitegromab2278276-46-1SRK-015阿匹特古单抗SRK015SRK 015TGF-beta/SmadTransforming growth factor betamonoclonal antibodyanti-promyostatinneuromuscular diseasespinal muscular atrophyInhibitorinhibitorinhibit

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