2. Apoptosis
  3. TNF Receptor
  4. Atrosimab

Atrosimab  (Synonyms: ATM-001)

目录号: HY-P991049 纯度: 98.00%
COA 技术支持

Atrosimab (ATM-001) 是一种 Fv-Fc1κ 融合蛋白，与人 TNFR1 强结合，EC50 值为 0.37 nM。Atrosimab 有效抑制 TNF 诱导的 TNFR1 激活。Atrosimab 具有研究慢性炎症性疾病的潜力。

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规格 价格 是否有货 数量
1 mg ￥7500
In-stock
5 mg ￥20000
In-stock
10 mg   询价  
50 mg   询价  

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Atrosimab 相关抗体

Top Publications Citing Use of Products

查看 TNF Receptor 亚型特异性产品:

查看所有亚型
TNFRSF1A/CD120a TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Atrosimab (ATM-001) is a Fv-Fc1κ fusion protein with strong binding to human TNFR1 with an EC50 value of 0.37 nM. Atrosimab potently inhibits TNF-induced activation of TNFR1. Atrosimab has the potential for the study of chronic inflammatory diseases[1].

同型

Fv-Fc
Clinical Trial
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

72.338 kDa

性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Fv-Fc1κ
Biological Activity
  • Loaded Atrosimab on ProA biosensor, can bind TNFR-1/CD120a Protein, Human (HEK293, His, HY-P700263) with an affinity constant of 2.076E-09 M as determined in BLI assay.
纯度 & 产品资料
参考文献

Atrosimab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AtrosimabATM-001ATM001ATM 001TNF ReceptorTumor Necrosis Factor ReceptorTNFRTNFR1 AntagonistInhibitorinhibitorinhibit

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