2. Biology Dictionary
  3. Lysine specific demethylase 1 (LSD1)

Lysine specific demethylase 1 (LSD1)赖氨酸特异性脱甲基酶 1

释义：

Lysine-specific demethylase 1(LSD1) also known as KDM1A, is the first discovered histone lysine demethylase. LSD1 has the ability to demethylase H3K4me1/2 and H3K9me1/2 at target loci in a context-dependent manner. LSD1 regulates the balance between self-renewal and differentiation of stem cells. LSD1 is highly expressed in various cancers and mediates differentiation and self-renewal of tumor cells.

赖氨酸特异性脱甲基酶 1 (LSD1) 也称为 KDM1A，是第一个被发现的组蛋白赖氨酸脱甲基酶。LSD1 能够在目标位点对 H3K4me1/2 和 H3K9me1/2 进行去甲基化。LSD1 调节干细胞自我更新和分化之间的平衡。LSD1 在多种癌症中高表达，并介导肿瘤细胞的分化和自我更新。

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