2. Metabolic Enzyme/Protease
  3. Mitochondrial Metabolism Phosphodiesterase (PDE)
  4. BJH-86

BJH-86 是一种可溶性线粒体复合体 1 (mitochondrial complex 1) 抑制剂 (氧消耗率抑制的 IC50 = 5 μM)。BJH-86 对磷酸二酯酶 10A (PDE10A) 的抑制活性较弱 (IC50 大于 10 μM)。BJH-86 可减少细胞耗氧量并抑制癌细胞增殖。BJH-86 可用于癌症研究，如肺癌。

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BJH-86

BJH-86 Chemical Structure

CAS No. : 3067849-10-6

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BJH-86 相关抗体

Top Publications Citing Use of Products

查看 Phosphodiesterase (PDE) 亚型特异性产品:

查看所有亚型
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BJH-86 is a soluble mitochondrial complex 1 inhibitor (oxygen consumption rate inhibition IC50 = 5 μM). BJH-86 exhibits weak inhibitory activity against phosphodiesterase 10A (PDE10A) (IC50 >10 μM). BJH-86 can reduce cellular oxygen consumption and inhibit cancer cell proliferation. BJH-86 can be used for the research of cancer, such as lung cancer[1].

IC50 & Target[1]

PDE10A

 

体外研究
(In Vitro)

BJH-86 (1-10 μM, 30 min-96 h) 在 A549 人肺癌细胞和 EO771 小鼠乳腺癌细胞中能有效抑制线粒体复合体 I (氧消耗率抑制的 IC50 = 5 μM)[1]。 BJH-86 对磷酸二酯酶 10A (PDE10A) 表现出较弱的抑制活性 (IC50 大于 10 μM)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BJH-86 相关抗体:
体内研究
(In Vivo)

BJH-86 (2-30 mg/kg，静脉注射) 可抑制携带 EO771 异种移植物的 C57Bl6 小鼠的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57Bl6 mice bearing EO771 xenografts[1]
Dosage: 2 mg/kg single dose 1 h before radiotherapy and 30 mg/kg repeated administration
Administration: Intravenously injection
Result: Reduced tumor hypoxia.
Enhanced radiosensitivity (5 Gy) .
Prolonged tumor growth delay from 2 days to 4 days.
分子量

371.43

Formula

C23H21N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BJH-86 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BJH-863067849-10-6BJH86BJH 86Mitochondrial MetabolismPhosphodiesterase (PDE)mitochondrial complex 1PDE10Aoxygen consumptioncancerA549breast cancerInhibitorinhibitorinhibit

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