2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. Bromopride hydrochloride

Bromopride hydrochloride 是一种选择性、不可逆、竞争性、口服有效的多巴胺 D2 受体拮抗剂。Bromopride hydrochloride 可通过血脑屏障，抑制呕吐中枢并增强胃肠动力，发挥止吐和促胃肠蠕动作用。Bromopride hydrochloride 拮抗多巴胺介导的呕吐反射及促进胃肠道平滑肌收缩，对术后腹腔感染大鼠的腹壁愈合无不良影响。Bromopride hydrochloride 可用于消化系统疾病 (如胃动力不足、恶心呕吐) 的研究。

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Bromopride hydrochloride Chemical Structure

Bromopride hydrochloride Chemical Structure

CAS No. : 52423-56-0

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Bromopride hydrochloride 的其他形式现货产品:

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Other Forms of Bromopride hydrochloride:

Bromopride hydrochloride 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bromopride hydrochloride is a selective, irreversible, competitive, and orally active dopamine D2 receptor antagonist. Bromopride hydrochloride can pass through the blood-brain barrier, inhibit the vomiting center, and enhance gastrointestinal motility, exerting antiemetic and gastrointestinal motility effects. Bromopride hydrochloride antagonizes dopamine-mediated vomiting reflexes and promotes gastrointestinal smooth muscle contraction, and has no adverse effects on abdominal wall healing in rats with postoperative abdominal infection. Bromopride hydrochloride can be used for the study of digestive system diseases (such as gastric hypomotility, nausea and vomiting)[1][2].

体外研究
(In Vitro)

轴突再生实验：Bromopride hydrochloride (100 μM；5 d) 在大鼠皮质神经元刮伤模型中，显著促进轴突再生，逆转硫酸软骨素蛋白聚糖 (CSPG) 对轴突生长的抑制作用[1]。
代谢物分析实验：Bromopride hydrochloride (10 μM；4 h) 在小鼠、大鼠、兔、狗、猴和人肝细胞中，可代谢为 20 种代谢物[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Bromopride hydrochloride 相关抗体:

Cell Viability Assay[1]

Cell Line: Rat embryonic cortical neurons (21 DIV), mouse dorsal root ganglion (DRG) neurons
Concentration: 100 μM
Incubation Time: 5 days (cortical scrape); 24 hours (DRG)
Result: Increased axon regeneration into the lesion area by ~1.6-fold compared to CSPG-treated controls in rat cortical cultures wounded at 21 DIV, as quantified by βIII-tubulin immunostaining and image analysis.
Enhanced total axon length per neuron in adult mouse DRG neurons cultured on CSPG-coated plates, demonstrating its ability to counteract CSPG-mediated growth inhibition.
体内研究
(In Vivo)

大鼠性行为模型：Bromopride (20-60 mg；静脉注射；单次) hydrochloride 剂量依赖性抑制雄性大鼠交配行为 (如延长射精后潜伏期)，并升高血清泌乳素水平[2]。
大鼠腹膜炎模型：Bromopride (1 mg/kg；皮下注射；每 12 小时；3/7 天) hydrochloride 在诱导腹膜炎的 Wistar 大鼠中，术后 7 天组腹壁伤口水肿和纤维蛋白沉积显著减少，且不影响伤口断裂强度[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (90-120 days, 350-575 g) with induced peritoneal sepsis via cecal ligation/perforation + left colon resection/anastomosis[3]
Dosage: 1 mg/kg Bromopride
Administration: Subcutaneous injection every 12 h until euthanasia (postoperative day 3 or 7)
Result: Reduced abdominal wall edema (p=0.041) and fibrin deposition (p=0.041) compared to controls (GC7) on day 7, with no significant difference in wound breaking strength. No adverse effects on survival or clinical signs (apathy, diarrhea) were observed.
Clinical Trial
分子量

380.71

Formula

C14H23BrClN3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Bromopride hydrochloride 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bromopride52423-56-0Dopamine ReceptorInhibitorinhibitorinhibit

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