2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. Bromopride

Bromopride  (Synonyms: 溴灭吐灵)

目录号: HY-B1164 纯度: 99.87%
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Bromopride 是一种选择性、不可逆、竞争性、口服有效的多巴胺 D2 受体拮抗剂。Bromopride 可通过血脑屏障，抑制呕吐中枢并增强胃肠动力，发挥止吐和促胃肠蠕动作用。Bromopride 拮抗多巴胺介导的呕吐反射及促进胃肠道平滑肌收缩，对术后腹腔感染大鼠的腹壁愈合无不良影响。Bromopride 可用于消化系统疾病 (如胃动力不足、恶心呕吐) 的研究。

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Bromopride

Bromopride Chemical Structure

CAS No. : 4093-35-0

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规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ￥616
In-stock
5 mg ￥560
In-stock
10 mg ￥880
In-stock
25 mg ￥1760
In-stock
50 mg ￥2800
In-stock
100 mg ￥4400
In-stock
200 mg 现货 询价
500 mg 现货 询价
1 g   询价  
5 g   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Bromopride:

Bromopride 相关抗体

Top Publications Citing Use of Products

查看 Dopamine Receptor 亚型特异性产品:

查看所有亚型
Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bromopride is a selective, irreversible, competitive, and orally effective dopamine D2 receptor antagonist. Bromopride can pass through the blood-brain barrier, inhibit the vomiting center, and enhance gastrointestinal motility, exerting antiemetic and gastrointestinal motility effects. Bromopride antagonizes dopamine-mediated vomiting reflexes and promotes gastrointestinal smooth muscle contraction, and has no adverse effects on abdominal wall healing in rats with postoperative abdominal infection. Bromopride can be used for the study of digestive system diseases (such as gastric hypomotility, nausea and vomiting)[1][2].

IC50 & Target

D2 Receptor

 

体外研究
(In Vitro)

轴突再生实验：Bromopride (100 μM；5 d) 在大鼠皮质神经元刮伤模型中，显著促进轴突再生，逆转硫酸软骨素蛋白聚糖 (CSPG) 对轴突生长的抑制作用[1]。
代谢物分析实验：Bromopride (10 μM；4 h) 在小鼠、大鼠、兔、狗、猴和人肝细胞中，可代谢为 20 种代谢物[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Bromopride 相关抗体:

Cell Viability Assay[1]

Cell Line: Rat embryonic cortical neurons (21 DIV), mouse dorsal root ganglion (DRG) neurons
Concentration: 100 μM (cortical scrape assay); unspecified (DRG assay, inferred from context)
Incubation Time: 5 days (cortical scrape); 24 hours (DRG)
Result: Increased axon regeneration into the lesion area by ~1.6-fold compared to CSPG-treated controls in rat cortical cultures wounded at 21 DIV, as quantified by βIII-tubulin immunostaining and image analysis.
Enhanced total axon length per neuron in adult mouse DRG neurons cultured on CSPG-coated plates, demonstrating its ability to counteract CSPG-mediated growth inhibition.
体内研究
(In Vivo)

大鼠性行为模型：Bromopride (20-60 mg；静脉注射；单次) 剂量依赖性抑制雄性大鼠交配行为 (如延长射精后潜伏期)，并升高血清泌乳素水平[2]。
大鼠腹膜炎模型：Bromopride (1 mg/kg；皮下注射；每 12 小时；3/7 天) 在诱导腹膜炎的 Wistar 大鼠中，术后 7 天组腹壁伤口水肿和纤维蛋白沉积显著减少，且不影响伤口断裂强度[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (90-120 days, 350-575 g) with induced peritoneal sepsis via cecal ligation/perforation + left colon resection/anastomosis[3]
Dosage: 1 mg/kg
Administration: Subcutaneous injection every 12 h until euthanasia (postoperative day 3 or 7)
Result: Rreduced abdominal wall edema (p=0.041) and fibrin deposition (p=0.041) compared to controls (GC7) on day 7, with no significant difference in wound breaking strength. No adverse effects on survival or clinical signs (apathy, diarrhea) were observed.
Clinical Trial
分子量

344.25

Formula

C14H22BrN3O2
CAS 号
性状

固体

颜色

Off-white to light yellow

中文名称

溴必利；溴灭吐灵
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 170 mg/mL (493.83 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9049 mL 14.5243 mL 29.0487 mL
5 mM 0.5810 mL 2.9049 mL 5.8097 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Bromopride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9049 mL 14.5243 mL 29.0487 mL 72.6216 mL
5 mM 0.5810 mL 2.9049 mL 5.8097 mL 14.5243 mL
10 mM 0.2905 mL 1.4524 mL 2.9049 mL 7.2622 mL
15 mM 0.1937 mL 0.9683 mL 1.9366 mL 4.8414 mL
20 mM 0.1452 mL 0.7262 mL 1.4524 mL 3.6311 mL
25 mM 0.1162 mL 0.5810 mL 1.1619 mL 2.9049 mL
30 mM 0.0968 mL 0.4841 mL 0.9683 mL 2.4207 mL
40 mM 0.0726 mL 0.3631 mL 0.7262 mL 1.8155 mL
50 mM 0.0581 mL 0.2905 mL 0.5810 mL 1.4524 mL
60 mM 0.0484 mL 0.2421 mL 0.4841 mL 1.2104 mL
80 mM 0.0363 mL 0.1816 mL 0.3631 mL 0.9078 mL
100 mM 0.0290 mL 0.1452 mL 0.2905 mL 0.7262 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bromopride4093-35-0溴必利溴灭吐灵Dopamine ReceptorInhibitorinhibitorinhibit

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