2. Epigenetics TGF-beta/Smad
  3. PKC
  4. Bryostatin 3

Bryostatin 3，一种大环内酯，是一种蛋白激酶 C 激活剂，Ki 值为 2.75 nM。Bryostatin 3 可以阻断 TPA 对细胞增殖的抑制作用，但不阻断 TPA 增强的细胞-基质粘附。

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Bryostatin 3 Chemical Structure

Bryostatin 3 Chemical Structure

CAS No. : 143370-84-7

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规格 价格 是否有货 数量
10 μg ￥5767
3 - 4 周

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Bryostatin 3 相关抗体

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKCι

  • 生物活性

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  • 参考文献

生物活性

Bryostatin 3, a macrocyclic lactone, is a protein kinase C activator, with a Ki of 2.75 nM. Bryostatin 3 can block 12-O-tetradecanoylphorbol-13-acetate (TPA) inhibition of cell proliferation, yet did not block TPA-enhanced cell-substratum adhesion[1][2].

IC50 & Target

Ki: 2.75 nM (protein kinase C)[1]
体外研究
(In Vitro)

Bryostatin 3 (1 μM; 24 h) does not inhibit [3Hlthymidine incorporation and largely blocks the growth-inhibitory action of TPA[2].
Bryostatin 3 (1 μM; 24 h) blocks the action of TPA to inhibit cell proliferation but does not block TPA-enhanced cell-substratum adhesion[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Bryostatin 3 相关抗体:
分子量

888.99

Formula

C46H64O17
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Bryostatin 3 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bryostatin 3143370-84-7Bryostatin3Bryostatin-3PKCProtein kinase CproteinkinaseC12-O-tetradecanoylphorbol-13-acetateTPAInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-108602
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