1. GPCR/G Protein Immunology/Inflammation
  2. CCR
  3. C-021 dihydrochloride

C-021 dihydrochloride 是有效的 CC 趋化因子受体 4 (CCR4) 拮抗剂。C-021 dihydrochloride 有效抑制人和小鼠的功能趋化性,IC50 分别为 140 nM 和 39 nM。C-021 dihydrochloride 以 IC50 为 18 nM 来有效阻止人 CCL22 衍生的 [35S]GTPγS 与受体结合。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

C-021 dihydrochloride Chemical Structure

C-021 dihydrochloride Chemical Structure

CAS No. : 1784252-84-1

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
1 mg ¥600
In-stock
5 mg ¥1200
In-stock
10 mg ¥1900
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of C-021 dihydrochloride:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

C-021 dihydrochloride is a potent CC chemokine receptor-4 (CCR4) antagonist. C-021 dihydrochloride potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM, respectively. C-021 dihydrochloride effectively prevents human CCL22-derived [35S]GTPγS from binding to the receptor with an IC50 of 18 nM[1].

IC50 & Target[1]

CCR4

 

体外研究
(In Vitro)

The in vitro oxidative metabolic stability of C-021 (Compound 1b) is evaluated by measuring the rate of drug consumption in human liver microsomes (HML), thus providing intrinsic clearance values (CLint). C-021 exhibits CLint value of 17,377 mL/h/kg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

The potency of C-021 (Compound 1b) is evident after subcutaneous administration in the murine oxazolone-induced contact hypersensitivity test, a known model of acute skin inflammation. When C-021 is administered orally, however, very little inhibition is observed[1].
C-021 (1 mg/kg; i.p.; daily; for 3 days) significantly less microgliosis in acute liver failuremice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57Bl/6 mice (20-25 g) with acute liver failure[2]
Dosage: 1 mg/kg
Administration: i.p.; daily; for 3 days
Result: Significantly less microgliosis, and significantly reduced the pERK1/2 to tERK1/2 ratio.
分子量

540.57

Formula

C27H43Cl2N5O2

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验: 

DMSO 中的溶解度 : 125 mg/mL (231.24 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

H2O 中的溶解度 : 27.0285 mg/mL (50.00 mM; 超声加热助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8499 mL 9.2495 mL 18.4990 mL
5 mM 0.3700 mL 1.8499 mL 3.6998 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳,请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度,如有需要,请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 99.92%

参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 1.8499 mL 9.2495 mL 18.4990 mL 46.2475 mL
5 mM 0.3700 mL 1.8499 mL 3.6998 mL 9.2495 mL
10 mM 0.1850 mL 0.9249 mL 1.8499 mL 4.6247 mL
15 mM 0.1233 mL 0.6166 mL 1.2333 mL 3.0832 mL
20 mM 0.0925 mL 0.4625 mL 0.9249 mL 2.3124 mL
25 mM 0.0740 mL 0.3700 mL 0.7400 mL 1.8499 mL
30 mM 0.0617 mL 0.3083 mL 0.6166 mL 1.5416 mL
40 mM 0.0462 mL 0.2312 mL 0.4625 mL 1.1562 mL
DMSO 60 mM 0.0308 mL 0.1542 mL 0.3083 mL 0.7708 mL
80 mM 0.0231 mL 0.1156 mL 0.2312 mL 0.5781 mL
100 mM 0.0185 mL 0.0925 mL 0.1850 mL 0.4625 mL

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
C-021 dihydrochloride
目录号:
HY-103364A
需求量: