2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. Calciseptine TFA

Calciseptine TFA，一种可从黑曼巴蛇 (Dendroaspis p. polylepis) 毒液中发现的天然多肽毒素。Calciseptine TFA 是 Cav1.2 亚型的 L 型通道的高效、选择性阻断剂，其 IC50 值为 92 nM。Calciseptine TFA 对 Cav3.1、Cav2.2、Cav2.1、Cav1.1、电压敏感性钠通道和钾通道无影响。Calciseptine TFA 对小鼠具有负性肌力和负性松弛效应，且不影响心率、对窦房结起搏细胞动作电位无影响。Calciseptine TFA 可用于研究心血管疾病。

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Custom Peptide Synthesis

Calciseptine TFA

Calciseptine TFA Chemical Structure

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Calciseptine TFA 相关抗体

Top Publications Citing Use of Products

查看 Calcium Channel 亚型特异性产品:

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Calciseptine TFA is a natural peptide toxin found in the venom of the black mamba snake (Dendroaspis p. polylepis). Calciseptine TFA is a highly effective and selective blocker of the L-type channel of the Cav1.2 subtype, with an IC50 value of 92 nM. Calciseptine TFA has no effect on Cav3.1, Cav2.2, Cav2.1, Cav1.1, voltage-sensitive sodium channels and potassium channels. Calciseptine TFA has negative inotropic and negative relaxant effects on mice, and does not affect heart rate or the action potential of sinoatrial node pacemaker cells. Calciseptine TFA can be used for the study of cardiovascular diseases[1].

IC50 & Target[1]

Cav1.2

92 nM (IC50)

分子量

7036.12 (free base)

Formula

C299H468N90O87S10.xC2HF3O2
Sequence

Arg-Ile-Cys-Tyr-Ile-His-Lys-Ala-Ser-Leu-Pro-Arg-Ala-Thr-Lys-Thr-Cys-Val-Glu-Asn-Thr-Cys-Tyr-Lys-Met-Phe-Ile-Arg-Thr-Gln-Arg-Glu-Tyr-Ile-Ser-Glu-Arg-Gly-Cys-Gly-Cys-Pro-Thr-Ala-Met-Trp-Pro-Tyr-Gln-Thr-Glu-Cys-Cys-Lys-Gly-Asp-Arg-Cys-Asn-Lys (Disulfide bridge:Cys3-Cys22;Cys17-Cys39;Cys41-Cys52; Cys53-Cys58)
Sequence Shortening

RICYIHKASLPRATKTCVENTCYKMFIRTQREYISERGCGCPTAMWPYQTECCKGDRCNK (Disulfide bridge:Cys3-Cys22;Cys17-Cys39;Cys41-Cys52; Cys53-Cys58)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Calciseptine TFA 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CalciseptineCalcium ChannelCa2+ channelsCa channelsL-type calcium channelsCav1.2 selectivityCav1.3 resistanceNegative inotropyHeart automaticitySnake venom toxinInhibitorinhibitorinhibit

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