1. NF-κB
  2. Keap1-Nrf2
  3. CBR-470-2

CBR-470-2 

目录号: HY-134001
产品使用指南

CBR-470-2 是甘氨酸取代的类似物,可以激活 NRF2 信号传导。CBR-470-2 可用于调节糖酵解。

MCE 的所有产品仅用作科学研究,我们不为任何个人用途提供产品和服务

CBR-470-2 Chemical Structure

CBR-470-2 Chemical Structure

CAS No. : 2416095-00-4

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

Description

CBR-470-2, a glycine-substituted analog, and can activate NRF2 signaling. CBR-470-2 can be used for modulation glycolysis[1].

IC50 & Target

NRF2[1]

In Vitro

CBR-470-2 (1-10 μM; 24 h) increases transcript levels of the NRF2-responsive genes NQO1 and HMOX1 in epidermal keratinocytes and dermal fibroblasts[1].

In Vivo

CBR-470-2 (50 mg/kg; p.o. twice daily for 10 d) induces activation of NRF2 signaling in vivo[1].

Animal Model: Balb/C mice (5-week old) are exposed to UVB[1]
Dosage: 50 mg/kg
Administration: P.o. twice daily for 10 days
Result: Resulted in comparable beneficial effects on erythema histological scores and total wounded area.
Decreased epidermal thickness in response to UV exposure.
Molecular Weight

402.27

Formula

C₁₂H₁₃Cl₂NO₆S₂

CAS No.

2416095-00-4

SMILES

OC(CN[C@@H](C1)[C@@H](S(C2=CC=C(Cl)C(Cl)=C2)(=O)=O)CS1(=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

CBR-470-2Keap1-Nrf2NRF2signalingmodulationglycolysisInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
CBR-470-2
目录号:
HY-134001
需求量: