CD31  (Synonyms: PECAM-1)

CD31 (PECAM-1) is platelet endothelial cell adhesion molecule-1, serves as the endothelial cell-specific receptor of clostridium perfringens b-Toxin (CPB). CD31 is also an ER-MP12 antigen, acts as a linker between mechanical stress, metabolism and inflammation. CD31 peptide is able to sustain phosphorylation of the CD31 ITIM₆₈₆ and of SHP2 and to inhibit TCR-induced T-cell activation^[1]-[5].

CD31 is a trans-homophilic co-signaling protein at the crossroad between mechanical stress, metabolism and inflammation^[1].
CD31 is a ER-MP12 antigen, exerts function as promoting cell adhesion between endothelial cells, enabling transmigration of leukocytes across vascular endothelium, and producing signaling to up-regulation of other adhesion molecules in neighboring cells^[2].
Clostridium perfringens b-toxin (CPB) is a highly active b-pore-forming toxin (b-PFT) and the essential virulence factor for fatal, necro-hemorrhagic enteritis^[3].
CD31 serves as the specific membrane receptor for clostridium perfringens b-toxin (CPB) on endothelial cells. CD31 directly interacts with CPB, with the membrane proximal Ig6 domain^[3].
CD31 also serves as a therapeutic target in atherosclerosis^[4].
CD31 (0, 25, 50, 100 μg/mL) induces proliferative response to TCR engagement of human PBMCs in a dose-dependent manner^[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

2601.10

C₁₁₉H₂₀₂N₃₆O₂₉

161374-99-8

NHASSVPRSKILTVRVILAPWKK

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• [1]. Caligiuri G. Mechanotransduction, immunoregulation, and metabolic functions of CD31 in cardiovascular pathophysiology. Cardiovasc Res. 2019 Jul 1. 115(9):1425-1434.  [Content Brief]

  [2]. Ling V, et al. Structural identification of the hematopoietic progenitor antigen ER-MP12 as the vascular endothelial adhesion molecule PECAM-1 (CD31). Eur J Immunol. 1997 Feb. 27(2):509-14.  [Content Brief]

  [3]. Bruggisser J, et al. CD31 (PECAM-1) Serves as the Endothelial Cell-Specific Receptor of Clostridium perfringens β-Toxin. Cell Host Microbe. 2020 Jul 8. 28(1):69-78.e6.  [Content Brief]

  [4]. Caligiuri G. CD31 as a Therapeutic Target in Atherosclerosis. Circ Res. 2020 Apr 24. 126(9):1178-1189.  [Content Brief]

  [5]. Fornasa G, et al. TCR stimulation drives cleavage and shedding of the ITIM receptor CD31. J Immunol. 2010 May 15. 184(10):5485-92.  [Content Brief]