2. Cell Cycle/DNA Damage Apoptosis
  3. CDK Apoptosis
  4. CDK2-IN-47

CDK2-IN-47 是一种强效的 CDK2 抑制剂，其 IC50 为 0.21 μM。CDK2-IN-47 对 MCF-7、HCT-116 和 MGC-803 细胞系表现出优异的抗癌活性。CDK2-IN-47 可有效诱导 G1 细胞周期停滞、视网膜母细胞瘤蛋白 (Rb) 去磷酸化和显著的细胞凋亡 (apoptosis)。CDK2-IN-47 可用于乳腺癌、结直肠癌和胃癌的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CDK2-IN-47

CDK2-IN-47 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

CDK2-IN-47 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CDK2-IN-47 is a potent CDK2 inhibitor with an IC50 of 0.21 μM. CDK2-IN-47 exhibits outstanding anticancer activity against MCF-7, HCT-116, and MGC-803 cell lines. CDK2-IN-47 effectively induces G1 cell cycle arrest, retinoblastoma protein (Rb) dephosphorylation, and significant apoptosis. CDK2-IN-47 can be used for the studies of breast cancer, colorectal cancer and gastric cancer[1].

IC50 & Target[1]

CDK2

0.21 μM (IC50)

CDK1

1.80 μM (IC50)

CDK7

8.70 μM (IC50)

CDK9

2.30 μM (IC50)

CDK4

> 10 μM (IC50)

CDK6

> 10 μM (IC50)

体外研究
(In Vitro)

CDK2-IN-47 (Compound 14c) (72 h) 对 MCF-7 (IC50 = 0.7 μM)、HCT-116 (IC50 = 1.1 μM) 和 MGC-803 (IC50 = 1.5 μM) 细胞系表现出优异的抗癌活性，并且对非癌性 HEK293 细胞具有显著的选择性 (SI = 22.4)[1]。
CDK2-IN-47 (0.7 μM, 48 h) 在 MCF-7 细胞中诱导显著细胞凋亡[1]。
CDK2-IN-47 (0.7 μM, 24 h) 在 MCF-7 中诱导 G0/G1 期细胞停滞细胞[1]。
CDK2-IN-47 导致 MCF-7 细胞中 Ser807/811 位点 Rb 磷酸化显著降低[1]。
CDK2-IN-47 在人肝微粒体中表现出较高的代谢稳定性 (t½ = 68.5 分钟，CLint = 8.5 mL/min/kg)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CDK2-IN-47 相关抗体:

Apoptosis Analysis[1]

Cell Line: MCF-7 cells
Concentration: 0.7 μM
Incubation Time: 48 h
Result: Reached the apoptosis rate by 38.5%.

Apoptosis Analysis[1]

Cell Line: MCF-7 cells
Concentration: 0.7 μM
Incubation Time: 24 h
Result: Induced G0/G1 phase arrest reached 68.7%.
分子量

381.45

Formula

C16H23N5O4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CDK2-IN-47 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK2-IN-47CDKApoptosisCyclin dependent kinaseCDK2 inhibitorsAnticancer agentsGlycerol conjugatesPeptide-drug conjugatesStructure-activity relationship (SAR)Molecular dockingInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
CDK2-IN-47
目录号：
HY-178112
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z