2. Apoptosis
  3. TNF Receptor
  4. Certolizumab pegol

Certolizumab pegol  (Synonyms: Certolizumab; CDP870)

目录号: HY-P9953 纯度: 99.30%
COA

摩尔计算器

Certolizumab pegol (Certolizumab) 是重组、聚乙二醇化、抗原结合片段的人源化单克隆抗体，可选择性靶向和中和肿瘤坏死因子-α (TNF-α)。 Certolizumab pegol 可用于类风湿关节炎和克罗恩病的研究。

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Certolizumab pegol Chemical Structure

Certolizumab pegol Chemical Structure

CAS No. : 428863-50-7

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1 mg ￥1800
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5 mg ￥3800
In-stock
10 mg ￥6000
In-stock
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100 mg   询价  

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Certolizumab pegol 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Certolizumab pegol (Certolizumab) is a recombinant, polyethylene glycolylated, antigen-binding fragment of a humanized monoclonal antibody that selectively targets and neutralizes tumour necrosis factor-α (TNF-α). Certolizumab pegol can be used for rheumatoid arthritis and Crohn disease research[1][2].

体外研究
(In Vitro)

Certolizumab pegol (Certolizumab) 中和可溶性 TNFα，IC90 为 3 ng/mL[2]。
Certolizumab pegol (0-100 μg/mL，1 h) 完全抑制人单核细胞响应 LPS 产生的 IL-1β[2]。
Certolizumab pegol 不介导补体依赖性细胞毒性 (CDC) 或抗体依赖性细胞介导的细胞毒性 (ADCC)[2]。
Certolizumab pegol 不会诱导活化的人单核细胞或外周血淋巴细胞 (PBL) 的凋亡，也不会导致脱颗粒或丢失多形核细胞的细胞膜完整性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Certolizumab pegol 相关抗体:
体内研究
(In Vivo)

Certolizumab pegol (Certolizumab) (10 μg；腹腔注射；单剂量) 可降低急性胰腺炎的严重程度[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Healthy Wistar Albino male rats weighing 180 to 200 g, acute edematous pancreatitis was induced via intraperitoneal injection of 80 μg/kg Cerulein (HY-A0190) (20 μg/kg, 4 times at 1-hour intervals)[3]
Dosage: 10 μg
Administration: Intraperitoneal administration, single dose
Result: Significantly decreased the serum levels of amylase, lipase, and lactate dehydrogenase. Histopathological edema, hemorrhage, parenchymal necrosis, and infiltration scores were also decreased, along with a decrease in malondialdehyde, myeloperoxidase, TNF-α, and caspase-3 activities.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

赛妥珠单抗
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 99.30%

COA (150 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Certolizumab pegol 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Certolizumab pegol428863-50-7Certolizumab CDP870赛妥珠单抗CDP870CDP 870CDP-870TNF ReceptorTumor Necrosis Factor ReceptorTNFRrheumatoid arthritisCrohn diseaseIL-1βacute pancreatitisInhibitorinhibitorinhibit

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