1. Apoptosis MAPK/ERK Pathway
  2. Apoptosis p38 MAPK
  3. Chromium picolinate

Chromium picolinate  (Synonyms: Chromium (III) picolinate; Cr(Pic)3)

目录号: HY-125588 纯度: 99.40%
COA 产品使用指南

Chromium picolinate (Chromium (III) picolinate) 是一种具有口服活性的化合物。Chromium picolinate 可诱导细胞凋亡 (apoptosis)。Chromium picolinate 是 p38 MAPK 的激活剂。Chromium picolinate 有抗氧化活性。Chromium picolinate 可用于 2 型糖尿病的研究。

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Chromium picolinate Chemical Structure

Chromium picolinate Chemical Structure

CAS No. : 14639-25-9

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10 mM * 1 mL in DMSO ¥550
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Customer Review

MCE 顾客使用本产品发表的 1 篇科研文献

查看 p38 MAPK 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Chromium picolinate (Chromium (III) picolinate) is a compound that has oral activity. Chromium picolinate induces apoptosis. Chromium picolinate is the activator of p38 MAPK. Chromium picolinate has antioxidant activity. Chromium picolinate can be used in research on type 2 diabetes[1][2][3][4].

体外研究
(In Vitro)

Chromium picolinate (5-100 μM, 24-72 h) 通过 ROS 和线粒体事件诱导淋巴细胞凋亡[1]
Chromium picolinate (100 nM, 24 h) 通过激活 p38 MAPK 在胰岛素抵抗的 3T3-L1 脂肪细胞中发挥降糖作用[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: lymphocytes
Concentration: 5,10, 25, 50, 75, 100 μM
Incubation Time: 24-72 h
Result: Inhibited cell viability from concentration of 25 μM.

Western Blot Analysis[1]

Cell Line: lymphocytes
Concentration: 50, 100 μM
Incubation Time: 24 h
Result: Increased the expression of Bax. and cytochrome.
Increased the activity of caspase-3.
体内研究
(In Vivo)

Chromium picolinate (100 mg/kg/day, 口服, 每天一次连续 4 周) 在 Goto-Kakizaki 糖尿病大鼠中可导致体重增加和胰岛素敏感性的改善[3]
Chromium picolinate (1 mg/kg/day, 口服, 每天一次连续 4 周) 可减轻链脲佐菌素 (HY-13753) 诱导的糖尿病大鼠高血糖的氧化应激反应[4]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Goto-Kakizaki diabetic rats [3]
Dosage: 100 mg/kg
Administration: p.o.
Result: Increased body weight.
The glucose levels were significantly lower in GK-CrP rats compared with GK-control rats.
Animal Model: Streptozotocin-induced diabetic rats[4]
Dosage: 1 mg/kg
Administration: p.o.
Result: Attenuated hyperglycemia and lowered lipid peroxidation in diabetic rats.
Restored the activity of SOD, catalase, GR, antioxidant capacity, ALT and AST.
Clinical Trial
分子量

418.30

Formula

C18H12CrN3O6

CAS 号
性状

固体

颜色

Pink to red

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 7.81 mg/mL (18.67 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.3906 mL 11.9531 mL 23.9063 mL
5 mM 0.4781 mL 2.3906 mL 4.7813 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Chromium picolinate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3906 mL 11.9531 mL 23.9063 mL 59.7657 mL
5 mM 0.4781 mL 2.3906 mL 4.7813 mL 11.9531 mL
10 mM 0.2391 mL 1.1953 mL 2.3906 mL 5.9766 mL
15 mM 0.1594 mL 0.7969 mL 1.5938 mL 3.9844 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Chromium picolinate
目录号:
HY-125588
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