2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. CMP8

CMP8 是雌激素受体 (estrogen receptor) 的选择性配体，可结合到雌激素受体配体结合域。CMP8 对突变型 MGERα、MGRERα 和野生型 hERα、hERβ 的IC50 值分别为 29 nM、41 nM、1100 nM 和2200 nM。

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CMP8

CMP8 Chemical Structure

CAS No. : 851107-28-3

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规格 价格 是否有货 数量
1 mg ￥3907
1 - 2 周
5 mg   询价  
10 mg   询价  

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CMP8 相关抗体

Top Publications Citing Use of Products

查看 Estrogen Receptor/ERR 亚型特异性产品:

查看所有亚型
Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CMP8, a selective ligand for estrogen receptor, binds to the mutant estrogen receptor ligand binding domain (ERLBD). CMP8 exhibits IC50 values of 29 nM , 41 nM, 1100 nM and 2200 nM for MGERα, MGRERα, hERα and hERβ, respectively[1][2].

IC50 & Target

MGERα

29 nM (IC50)

MGRERα

41 nM (IC50)

hERα

1100 nM (IC50)

hERβ

2200 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HeLa EC50
41 nM
Compound: 20h
Activity at ERalpha L384M/M421G/G521R mutant in HeLa cells assessed as activation of SEAP reporter gene
Activity at ERalpha L384M/M421G/G521R mutant in HeLa cells assessed as activation of SEAP reporter gene
[PMID: 16942012]
体内研究
(In Vivo)

CMP8 (Compound 20h) is dosed in male Balb-c mice (4 mg/kg, ip). The plasma concentration after 4 h is 1.5-fold its EC50 in mammalian cells with a Cmax of 0.5 µM after 30 min[1][2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

528.08

Formula

C33H34ClNO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CMP8 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CMP8851107-28-3CMP 8CMP-8Estrogen Receptor/ERRInhibitorinhibitorinhibit

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目录号：
HY-110392
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