2. GPCR/G Protein Metabolic Enzyme/Protease
  3. Adenosine Receptor Endogenous Metabolite
  4. CV1808

CV1808  (Synonyms: 2-Phenylaminoadenosine)

目录号: HY-103183 纯度: ≥98.0%
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摩尔计算器

CV1808 (2-Phenylaminoadenosine) 是一种非选择性 A2 腺苷受体 (A2 AR) 激动剂，对 A2A 和 A3 腺苷受体亚型的 Ki 分别为 76 和 1450 nM。

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CV1808 Chemical Structure

CV1808 Chemical Structure

CAS No. : 53296-10-9

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CV1808 相关抗体

Top Publications Citing Use of Products

查看 Adenosine Receptor 亚型特异性产品:

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Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CV1808 (2-Phenylaminoadenosine) is a non-selective A2 adenosine receptor (A2 AR) agonist with Kis of 76 and 1450 nM for A2A and A3 adenosine receptor subtypes, respectively[1].

体外研究
(In Vitro)

CV1808 demonstrates an inhibitory effect on anti-IgE-induced activation at 100 μM[1].
In the presence of Forskolin (1 μM in PC12 cells; 10 μM in Jurkat cells) the EC50 value for CV1808 is 2 μM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CV1808 相关抗体:
体内研究
(In Vivo)

Single afferent arterioles of Sprague-Dawley rats are visualized and superfused with solutions containing CV1808 (CV-1808). Superfusion with CV1808 (0.002-2 μM) dilates afferent arterioles[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rat, weighing 370-410 g[3]
Dosage: 0.002, 0.02, 0.2, and 2 μM
Administration: Single afferent arterioles of Sprague-Dawley rats were visualized and superfused with solutions containing CV-1808
Result: Afferent arteriolar diameter increased from 17.0±0.3 to 17.2±0.4, 17.8±0.4, 18.5±0.5, and 19.9±0.7 μM, 17.2±2.4% at concentrations of 0.002, 0.02, 0.2, and 2 μM.
分子量

358.35

Formula

C16H18N6O4
CAS 号
性状

固体

颜色

Off-white to light yellow

中文名称

2-苯基氨基腺苷
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

CV1808 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CV180853296-10-92-Phenylaminoadenosine2-苯基氨基腺苷CV 1808CV-1808Adenosine ReceptorEndogenous MetaboliteP1 receptorAdenosine,anti-IgE,asthma,histamine,humanmastcellsnon-selectiveadenosineInhibitorinhibitorinhibit

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