2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. Cyclo(glycyl-L-leucyl)

Cyclo(glycyl-L-leucyl)  (Synonyms: 环(甘氨酰-L-亮氨酰); Cyclo(leu-gly))

目录号: HY-W152604
产品使用指南

摩尔计算器

Cyclo(glycyl-L-leucyl) (Cyclo(leu-gly)) 是一种神经肽，可下调多巴胺 (DA) 受体并减弱多巴胺能超敏反应。Cyclo(glycyl-L-leucyl) 抑制大鼠中 Morphine 诱导的缓解疼痛和多巴胺受体超敏反应的发展。Cyclo(glycyl-L-leucyl) 具有预防迟发性和/或 L-DOPA.html" class="link-product" target="_blank">L-DOPA (HY-N0304) 诱发的运动障碍的潜力。

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Custom Peptide Synthesis

Cyclo(glycyl-L-leucyl) Chemical Structure

Cyclo(glycyl-L-leucyl) Chemical Structure

CAS No. : 5845-67-0

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Cyclo(glycyl-L-leucyl) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cyclo(glycyl-L-leucyl) (Cyclo(leu-gly)), a neuropeptide, down-regulates dopamine (DA) receptors and attenuates dopaminergic supersensitivity. Cyclo(glycyl-L-leucyl) inhibits the development of Morphine induced pain relief as well as dopamine receptor supersensitivity in rats. Cyclo(glycyl-L-leucyl) has the potential for the prevention of tardive and/or L-DOPA.html" class="link-product" target="_blank">L-DOPA (HY-N0304)-induced dyskinesias[1][2].

IC50 & Target[1]

Dopamine Receptor

 

体内研究
(In Vivo)

Cyclo(glycyl-L-leucyl) (8 mg/kg; 皮下给药) 在阿扑吗啡 (APO) 后 24 小时给予，可减弱由急性高剂量 APO (5 mg/kg; 皮下给药) 引起的 DA 受体超敏反应[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss-Webster mice, 20-25g[1]
Dosage: 8 mg/kg
Administration: SC; single dose given 24h after apomorphine (APO)
Result: Attenuated the DA receptor supersensitivity caused by acute high dose APO (5 mg/kg; s.c.).
分子量

170.21

Formula

C8H14N2O2
CAS 号
中文名称

环(甘氨酰-L-亮氨酰)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
纯度 & 产品资料
参考文献

Cyclo(glycyl-L-leucyl) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclo(glycyl-L-leucyl)5845-67-0Cyclo(leu-gly)环(甘氨酰-L-亮氨酰)Dopamine Receptorneuropeptidedopaminergic supersensitivityMorphinepaintardiveL-DOPA dyskinesiasInhibitorinhibitorinhibit

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