2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. CYP4Z1-IN-1

CYP4Z1-IN-1 (compound 7c) 是一种有效的 CYP4Z1 抑制剂，IC50 为 41.8 nM。 CYP4Z1-IN-1 在体外和体内以浓度依赖性方式降低乳腺癌症干细胞标记物的表达、球体形成和转移能力以及肿瘤启动能力。

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CYP4Z1-IN-1 Chemical Structure

CYP4Z1-IN-1 Chemical Structure

CAS No. : 2760611-38-7

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CYP4Z1-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Cytochrome P450 亚型特异性产品:

查看所有亚型
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CYP4Z1-IN-1 (compound 7c) is a potent CYP4Z1 inhibitor, with an IC50 of 41.8 nM. CYP4Z1-IN-1 decreases the expression of breast CSCs stemness markers, spheroid formation, and metastatic ability as well as tumor-initiation capability in a concentration-dependent manner in vitro and in vivo[1].

IC50 & Target

CYP4Z1

41.8 ± 1.4 nM (IC50)

CYP4F11

291.3 ± 46 nM (IC50)

CYP4F12

1598.3 ± 5 nM (IC50)

CYP2D6

>10 000 nM (IC50)

CYP2C9

>10 000 nM (IC50)

CYP3A4

>10 000 nM (IC50)

体外研究
(In Vitro)

CYP4Z1-IN-1 (compound 7c) 显示出对乳腺 CSC (癌症干细胞)的抗增殖活性，IC50 为 483 ± 2.5 nM[1] 。
CYP4Z1-IN-1 (0.8-51.2 μM, 24 h) 抑制乳腺癌细胞中干细胞标记物 (P-gp, Oct3/4, Nanog, ALDH1A1, 和 Sox2) 的表达[1]。
CYP4Z1-IN-1 (0.8-51.2 μM, 24-48 h) 可减弱乳腺癌细胞的迁移和侵袭能力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CYP4Z1-IN-1 相关抗体:

Western Blot Analysis[1]

Cell Line: MCF-7 and MDA-MB-231 cells
Concentration: 0.8 μM, 3.2 μM, 12.8 μM, 51.2 μM
Incubation Time: 24 h
Result: Significantly suppressed the protein expression of stemness markers (P-gp, Oct3/4, Nanog, ALDH1A1, and Sox2) in MCF-7 cells in a concentration-dependent manner.
体内研究
(In Vivo)

CYP4Z1-IN-1 (compound 7c) (2000 mg/kg，口服，连续 7 天)对小鼠没有明显的毒性和体重减轻[1]。
CYP4Z1-IN-1 (12.8 μM, 72 h处理MCF-7 and MDA-MB-231 cells，然后细胞皮下植入小鼠腹股沟乳腺) 可阻断乳腺癌细胞的肿瘤启动能力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice[1]
Dosage: 2000 mg/kg
Administration: orally, for 7 days
Result: Showed that compound 7c was rather safe; no evident toxicity and body weight loss were observed.
Animal Model: BALB/c-nude mice (3-4 week old, female)[1]
Dosage: 12.8 μM
Administration: MCF-7 and MDA-MB-231 cells were pre-treated with 7c (12.8 μM) for 72 h and were then implanted in the inguinal mammary gland of mice subcutaneously
Result: Blocked the tumor-initiating ability of breast cancer cells.
分子量

250.29

Formula

C13H18N2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CYP4Z1-IN-1 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CYP4Z1-IN-12760611-38-7Cytochrome P450CYPsCancer stem cellsCSCsMCF-7 cellsMDA-MB-231 cellsbreast cancerInhibitorinhibitorinhibit

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