1. Apoptosis
  2. Apoptosis
  3. DB818

DB818 是 Homeobox A9 (HOXA9) 的有效抑制剂。HOXA9 是一种调节造血和白血病细胞增殖的转录因子,与急性髓系白血病 (AML) 有关。DB818 抑制 AML 细胞生长,诱导凋亡 (apoptosis)。

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DB818 Chemical Structure

DB818 Chemical Structure

CAS No. : 790241-43-9

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规格 价格 是否有货 数量
1 mg ¥2045
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5 mg ¥4500
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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DB818 is a potent inhibitor of Homeobox A9 (HOXA9). HOXA9 is a transcription factor regulating haematopoiesis and leukaemia cell proliferation, involving in acute myeloid leukaemia (AML). DB818 inhibits AML cell lines growth, induces apoptosis[1].

IC50 & Target

Homeobox A9 (HOXA9)[1]

体内研究
(In Vivo)

DB818 (12.5 mg/kg, 25 mg/kg; 皮下给药,每天 1 次,连续 4 天) 在 25 mg/kg 剂量下,可完全治愈感染小虫的小鼠的寄生虫血症。剂量为 12.5 mg/kg时,2/3 小鼠被治愈[1]
DB818 导致小鼠感染后第 20 天左右出现复发[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

360.44

Formula

C19H16N6S

CAS 号
性状

固体

颜色

White to yellow

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 98.36%

参考文献

DB818 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
DB818
目录号:
HY-122623
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