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  4. Dermatan sulphate sodium

Dermatan sulphate sodium  (Synonyms: 硫酸软骨素B)

目录号: HY-N8278
COA 产品使用指南 技术支持

Dermatan sulphate sodium 是一种具有口服活性的糖胺聚糖和凝血酶灭活剂，具有抗血栓活性。Dermatan sulphate sodium 可选择性催化肝素辅因子 II 灭活凝血酶，且不与抗凝血酶 III 相互作用。Dermatan sulphate sodium 可促进干细胞分化，也具有高生物利用度，还能够减轻 Bleomycin (HY-108345) 诱导的肺纤维化损伤。Dermatan sulphate sodium 可用于心血管、炎症、干细胞分化领域研究。

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Dermatan sulphate sodium

Dermatan sulphate sodium Chemical Structure

CAS No. : 54328-33-5

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规格 价格 是否有货 数量
5 mg ￥1080
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10 mg ￥1620
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25 mg ￥2760
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50 mg ￥4160
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Dermatan sulphate sodium 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dermatan sulphate sodium is an oral active glycosaminoglycan and thrombin inactivator with antithrombotic activity. It selectively catalyzes the heparin cofactor II-mediated inactivation of thrombin without interacting with antithrombin III. Dermatan sulphate sodium promotes stem cell differentiation, exhibits high bioavailability, and alleviates pulmonary fibrosis injury induced by Bleomycin (HY-108345). Dermatan sulphate sodium can be used in research related to cardiovascular diseases, inflammation, and stem cell differentiation[1][2][3].

体外研究
(In Vitro)

Dermatan sulphate (10 μg/mL，7 天) sodium 促进神经分化和迁移，但不影响神经突生长 (hNSC)[3]。
Dermatan sulphate (100 μg/ml，12 天) sodium 促进神经分化并增强神经突生长 (mESCs)[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Dermatan sulphate sodium 相关抗体:

Real Time qPCR[3]

Cell Line: Human neural stem cells (hNSCs, from 14-week human fetal cerebral cortex)
Concentration: 10 μg/mL
Incubation Time: 7 days
Result: Significantly increased expression of neuronal markers (DCX, β-III-Tubulin).

Western Blot Analysis[3]

Cell Line: R1 mouse embryonic stem cells (mESCs, mouse, undifferentiated)
Concentration: 100 μg/mL
Incubation Time: 12 days
Result: Significantly enhanced p-Erk1/2 expression.
体内研究
(In Vivo)

Dermatan sulphate (5.3 mg/kg，口服灌胃，每日一次，连续 28 天) sodium 可在 Bleomycin (HY-108345) 诱导的 C57 小鼠肺纤维化模型中减轻肺部炎症与纤维化，并增强纤溶功能[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Bleomycin (HY-108345)-induced pulmonary fibrosis model in C57 mice[2]
Dosage: 5.3 mg/kg
Administration: Oral gavage (p.o.), once daily for 28 days
Result: Significantly reduced lung index, alleviated pulmonary edema, inflammatory infiltration, alveolar damage and collagen deposition;
Reduced lung hydroxyproline and plasma fibrinogen levels;
Increased plasma tPA levels.
CAS 号
性状

固体

颜色

White to off-white

中文名称

硫酸软骨素B
结构分类
初始来源

mammals and bacteria
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 100 mg/mL (超声助溶)

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
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体积
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分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

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体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
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由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

COA (200 KB)

产品使用指南 (1538 KB)
参考文献

Dermatan sulphate sodium 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dermatan sulphate54328-33-5硫酸软骨素BThrombinGlycosaminoglycansthrombinpulmonary fibrosis injuryinflammatory cell infiltrationInhibitorinhibitorinhibit

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