2. Membrane Transporter/Ion Channel Immunology/Inflammation Neuronal Signaling Metabolic Enzyme/Protease Apoptosis
  3. Calmodulin NO Synthase CaMK Calcineurin Proteasome Caspase
  4. DY-9760e

DY-9760e 是一种钙调蛋白 (CaM) 抑制剂。DY-9760e 通过拮抗 Ca²⁺/CaM 复合物，选择性抑制多种钙调蛋白依赖性酶的活性，对 nNOS、CaM 激酶 II (CaM kinase II) 和钙调神经磷酸酶 (calcineurin) 的 Ki 分别为 0.9、1.4 和 2.0 μM。DY-9760e 抑制一氧化氮过度生成与蛋白酪氨酸硝化、calpain 与 caspase-3 的激活。DY-9760e 缩小心梗死面积、改善心功能、抑制氧化应激与细胞死亡。DY-9760e 可用于研究心肌梗死、脑缺血等疾病。

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DY-9760e

DY-9760e Chemical Structure

CAS No. : 179185-73-0

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DY-9760e 相关抗体

Top Publications Citing Use of Products

查看 Calmodulin 亚型特异性产品:

查看所有亚型
CALM1 CALM2 CALM3

查看 NO Synthase 亚型特异性产品:

查看所有亚型
nNOS iNOS eNOS

查看 CaMK 亚型特异性产品:

查看所有亚型
CaMK II CaMK III/eEF-2K CAMK IV PHK Trio DCAMKL

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DY-9760e is a calmodulin (CaM) inhibitor. DY-9760e selectively inhibits the activity of various calmodulin-dependent enzymes by antagonizing the Ca²⁺/CaM complex, exhibiting the strongest inhibitory activity against nNOS, CaM kinase II, and calcineurin (Ki: 0.9, 1.4, and 2.0 μM, respectively). DY-9760e inhibits excessive nitric oxide production and protein tyrosine nitration, as well as the activation of calpain and caspase-3. DY-9760e reduces infarct size, improves cardiac function, and inhibits oxidative stress and cell death. DY-9760e can be used in research on the treatment of myocardial infarction, cerebral ischemia, and other diseases[1].

IC50 & Target[1]

nNOS

0.9 nM (Ki)

CaMK II

1.4 nM (Ki)

Caspase 3

 

分子量

630.50

Formula

C26H31ClN6O2.2ClH.7/2H2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DY-9760e 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DY-9760e179185-73-0CalmodulinNO SynthaseCaMKCalcineurinProteasomeCaspaseCaMCalcium-Modulated ProteinNitric oxide synthasesNOSCalmodulin-dependent protein kinasesCalmodulin-dependent kinasesPP2BPPP3Calmodulin antagonistCalpainCardiomyocytesCaspase-3IschemiaProtein tyrosine nitrationInhibitorinhibitorinhibit

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