1. Metabolic Enzyme/Protease
  2. Factor Xa Thrombin
  3. Edoxaban hydrochloride

Edoxaban hydrochloride  (Synonyms: 伊多塞班盐酸盐; DU-176 hydrochloride)

目录号: HY-10264C
产品使用指南

Edoxaban (DU-176b) hydrochloride 是一种具有口服活性、高效、选择性和直接的 Factor Xa (FXa) 抑制剂,对人游离 FXa 和凝血酶原酶的 Ki 值分别为 0.561 nM 和 2.98 nM。Edoxaban hydrochloride 的选择性是其他凝血蛋白酶的 10000 倍以上。Edoxaban hydrochloride 可用于预防血栓栓塞性疾病的研究。

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Edoxaban hydrochloride Chemical Structure

Edoxaban hydrochloride Chemical Structure

CAS No. : 480448-29-1

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规格 是否有货
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Edoxaban hydrochloride 的其他形式现货产品:

Customer Review

Other Forms of Edoxaban hydrochloride:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Edoxaban (DU-176b) hydrochloride is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Ki values of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban hydrochloride exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban hydrochloride can be used for preventing thromboembolic disease research[1].

IC50 & Target

IC50: 2.90 µM (platelet aggregation), Ki: 0.561 nM (free human FXa), 2.98 nM (prothrombinase), 0.715 nM (cynomolgus monkey FXa), 0.457 nM (rabbit FXa)[1]

体外研究
(In Vitro)

Edoxaban hydrochloride (1, 1 and 5 minutes respectively) prolongs PT,TT and APTT of human plasma in a concentration-dependent manner[1].
Edoxaban hydrochloride inhibits thrombin-induced platelet aggregation, with an IC50 of 2.90 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Human, rat, cynomolgus monkey and rabbit plasma; Human platelet
Concentration:
Incubation Time: 1 and 5 minutes
Result: Antithrombin.
体内研究
(In Vivo)

Edoxaban hydrochloride (0.5, 2.5 and 12.5 mg/kg; p.o.; once) significantly and dose-dependently reduces the thrombus formation and prolongs PT[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Slc: Wistar rats (210-240 g); Male New Zealand White rabbits(2.5-3.5 kg) (Both are venous stasis thrombosis model)[1].
Dosage: 0.5, 2.5 and 12.5 mg/kg
Administration: Oral administration; once
Result: Inhibited exogenous FXa activity.
Antithrombotic.
Clinical Trial
分子量

584.52

Formula

C24H31Cl2N7O4S

CAS 号
中文名称

伊多塞班盐酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Edoxaban hydrochloride
目录号:
HY-10264C
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