2. Antibody-drug Conjugate/ADC Related Protein Tyrosine Kinase/RTK
  3. Antibody-Drug Conjugates (ADCs) TAM Receptor
  4. Enapotamab vedotin

Enapotamab vedotin  (Synonyms: HuMax-AXL-ADC)

目录号: HY-P99921
产品使用指南 技术支持

Enapotamab vedotin 是一种靶向 AXL 的抗体-药物偶联物 (ADC)，具有抑制高 AXL 表达的非小细胞肺癌 (NSCLC) 的潜力。Enapotamab vedotin 也表现出对 EGFR 抑制剂（例如 Osimertinib (HY-15772)）的耐药性。

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Enapotamab vedotin

Enapotamab vedotin Chemical Structure

CAS No. : 1912424-97-5

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Enapotamab vedotin 相关抗体

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Axl Mer Tyro3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Enapotamab vedotin is an AXL-targeted antibody-drug conjugate (ADC) with inhibitory potential against high AXL expressing non-small cell lung cancer (NSCLC). Enapotamab vedotin also exhibits resistant to EGFR inhibitor such as Osimertinib (HY-15772)[1].

IC50 & Target

AXL[1]
体外研究
(In Vitro)

Enapotamab vedotin (0-10 μg/mL, 5 days) 在 AXL 高表达的细胞（如 ER20 和 H1975-OR2）中表现出细胞毒性，可以降低细胞活力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Enapotamab vedotin 相关抗体:

Cell Viability Assay[1]

Cell Line: ER20, H1975-OR2
Concentration: 0-10 μg/mL
Incubation Time: 5 days
Result: Reduced the cell viability.
体内研究
(In Vivo)

Enapotamab vedotin（2-4 mg/kg，静脉注射，每周一次，共注射两次）对多种 AXL 高表达的非小细胞肺癌 (NSCLC)（如 LU0395）表现出抗肿瘤功效，在 LU1868 或 LU0858 异种移植小鼠模型中表现出对 EGFR 抑制剂的耐药性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LU0395 xenograft mouse models[1]
Dosage: 2-4 mg/kg
Administration: iv, once weekly for 2 doses
Result: Inhibited the tumor growth.
CAS 号
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Enapotamab vedotin 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Enapotamab vedotin1912424-97-5HuMax-AXL-ADCAntibody-Drug Conjugates (ADCs)TAM ReceptorAntibody-Drug ConjugatesTyro3AxlMerInhibitorinhibitorinhibit

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