2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. Enpp-1-IN-28

Enpp-1-IN-28 是一种 ENPP1 抑制剂，在分子和细胞水平上的 IC50 值分别为 0.188 µM 和 0.732 µM。Enpp-1-IN-28 通过阻止 ENPP1 水解 cGAMP，在体内上调 IFN-β 的表达水平，从而激发更强的先天免疫反应。Enpp-1-IN-28 可用于转移性乳腺癌研究。

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Enpp-1-IN-28

Enpp-1-IN-28 Chemical Structure

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Customer Review

Enpp-1-IN-28 相关抗体

Top Publications Citing Use of Products

查看 Phosphodiesterase (PDE) 亚型特异性产品:

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PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Enpp-1-IN-28 is a ENPP1 inhibitor at the molecular and cellular levels, with IC50 values of 0.188 µM and 0.732 µM, respectively. Enpp-1-IN-28 upgrades the expression levels of IFN-β in vivo by preventing the ENPP1 from hydrolyzing the cGAMP to stimulate a more potent innate immune response. Enpp-1-IN-28 can be used for the study of metastatic breast cancer[1].

IC50 & Target[1]

ENPP1

0.188 μM (IC50, molecular levels)

ENPP1

0.732 μM (IC50, cellular levels)

体外研究
(In Vitro)

Enpp-1-IN-28 (Compound 4e) 对 4T1 细胞系显示出细胞毒性活性 (IC50 = 2.99 μM)，而在 50 μM 时对正常细胞系 (LO2 和 293T) 的细胞毒性作用不显著[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Enpp-1-IN-28 相关抗体:
体内研究
(In Vivo)

Enpp-1-IN-28 (Compound 4e) (0.5 mg/kg，静脉注射，单次剂量) 增加 BALB/c 裸鼠肿瘤模型血清中 IFN-β 的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4T1 breast cancer cells were subcutaneously implanted into 6-8-week-old BALB/c nude mice[1]
Dosage: 0.5 mg/kg combined with 5 mg/kg cGAMP
Administration: i.v. for a single dose
Result: Increased the expression level of IFN-β in the serum of BALB/c nude mice compared with the free cGAMP group.
Protected cGAMP from degradation by ENPP1, thereby stimulating a more potent innate immune response.
分子量

356.37

Formula

C17H13FN4O2S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Enpp-1-IN-28 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Enpp-1-IN-28Phosphodiesterase (PDE)ENPP1STINGinhibitormetastatic breast cancertumor immunotherapyInhibitorinhibit

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产品名称：
Enpp-1-IN-28
目录号：
HY-176828
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