2. Cell Cycle/DNA Damage
  3. Topoisomerase DNA/RNA Synthesis
  4. F-14512 hydrochloride

F-14512 hydrochloride 是一种抗癌剂，利用多胺转运系统 (PTS) 将含多胺的药物选择性地输送至癌细胞。F-14512 hydrochloride 通过多胺与 DNA 的亲和力增强拓扑异构酶 II (topoisomerase II) 抑制，并实现了选择性细胞摄取。F-14512 hydrochloride 对 PTS 活性高的细胞表现出显著的细胞毒性，并诱导了 DNA 损伤。F-14512 hydrochloride 在 MX1 乳腺肿瘤异种移植模型中，表现出强效的抗肿瘤活性。F-14512 hydrochloride 可用于研究乳腺癌。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

F-14512 hydrochloride

F-14512 hydrochloride Chemical Structure

CAS No. : 866874-39-7

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

F-14512 hydrochloride 的其他形式现货产品:

Customer Review

Other Forms of F-14512 hydrochloride:

F-14512 hydrochloride 相关抗体

Top Publications Citing Use of Products

查看 Topoisomerase 亚型特异性产品:

查看所有亚型
Topoisomerase Topo I Topo II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

F-14512 hydrochloride is an anticancer agent that utilizes the polyamine transport system (PTS) to selectively deliver polyamine-containing drugs to cancer cells. F-14512 hydrochloride enhances the affinity of polyamines for DNA, thereby inhibiting topoisomerase II and achieving selective cellular uptake. F-14512 hydrochloride exhibits significant cytotoxicity against cells with high PTS activity and induces DNA damage. F-14512 hydrochloride demonstrates potent antitumor activity in the MX1 breast tumor xenograft model. F-14512 hydrochloride could be used to study breast cancer[1].

体外研究
(In Vitro)

F-14512 (0.001-100 μM) hydrochloride 通过多胺转运系统进入细胞。在具有正常 PTS 的 CHO 细胞中，IC50 为 0.12 μM；而在 PTS 缺陷的 CHO-MG 细胞中，IC50 为 8.7 μM[1]。
F-14512 (72 h) hydrochloride 在多种人类细胞系中表现出高效性 (中位 IC50 = 0.18 μM)，尤其对 MX-1、LOX-IMV1 和 HL-60 等细胞系有效[1]。
F-14512 (1-100 μM，1-24 h) hydrochloride 可诱导 A549 细胞 DNA 损伤，并在具有 DNA 缺陷的 xrs6 细胞中表现出更强的细胞毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

F-14512 hydrochloride 相关抗体:
体内研究
(In Vivo)

F-14512 (0.16-1.25 mg/kg，腹腔注射，每日一次，持续 2 周) hydrochloride 在 MX-1 模型中表现出优异的抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MX-1 human breast cancer xenograft model established in homozygous female athymic nude mice[1]
Dosage: 0.16, 0.32, 0.63, 1.25 mg/kg
Administration: Intraperitoneal injection (i.p.), once daily for 2 weeks
Result: Led to tumor regression dose-dependently.
分子量

787.60

Formula

C33H51Cl4N5O8
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

F-14512 hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

F-14512866874-39-7F14512F 14512TopoisomeraseDNA/RNA SynthesisantitumorMX1 human breast tumor xenograft modelpolyamine transport systemPTSInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
F-14512 hydrochloride
目录号：
HY-106031A
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z