2. Cytoskeleton
  3. Gap Junction Protein
  4. Gap19

Gap19 是一种衍生自 Cx43 细胞质环 (CL) 九个氨基酸的肽，一种有效的，选择性连接蛋白 43 (Cx43) 半通道阻滞剂。Gap19 可以防止 C 末端 (CT) 与 CL 的分子内相互作用。Gap19 不阻断 GJ 通道或 Cx40/pannexin-1 半通道。Gap19 对心肌具有保护作用。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Gap19 TFA 通常具有更好的水溶性和稳定性。

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Gap19 Chemical Structure

Gap19 Chemical Structure

CAS No. : 1507930-57-5

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Gap19 的其他形式现货产品:

Customer Review

Other Forms of Gap19:

Gap19 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Gap19, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 has protective effects against myocardial[1][2].

IC50 & Target

Cx43 Hemichannel[1]
体外研究
(In Vitro)

Gap19 (250 μM; for 30 min ) decreases mitochondrial potassium uptake[1].
Gap19 (400 μM) inhibits unitary hemichannel currents in HeLa-Cx43 cells[2].
Gap19 (100 μM) inhibits hemichannel unitary currents in ventricular cardiomyocytes[2].
Gap19 (250 μM, 30 min) protects against myocardial ischemia/reperfusion injury in vitro and in vivo[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Gap19 相关抗体:
体内研究
(In Vivo)

Gap19 (iv; 25 mg/kg; 10 min before ligation) significantly reduces the infarct size by approximately one-fifth[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57/BL6 mice[2]
Dosage: 25 mg/kg
Administration: IV; 10 min before ligation
Result: Significantly reduced the infarct size by approximately one-fifth.
分子量

1161.44

Formula

C55H96N14O13
CAS 号
Sequence Shortening

KQIEIKKFK
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Gap19 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gap191507930-57-5Gap 19Gap-19Gap Junction ProteinCx43connexinhemichannelC-terminusCTcytoplasmicloopCLGJchannelsCx40/pannexin-1myocardialInhibitorinhibitorinhibit

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