1. Gene
  2. KAT5 - lysine acetyltransferase 5 Gene

KAT5 - lysine acetyltransferase 5 Gene

中文名称:赖氨酸乙酰转移酶 5

种属: Homo sapiens


基因 ID: 10524 | 基因类型: protein coding

关于 KAT5

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,712,018-65,719,604 (from NCBI)

This gene has 17 transcripts (splice variants), 104 orthologues, 9 paralogues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 21.5), thyroid (RPKM 20.0) and 25 other tissues.


由该基因编码的蛋白质属于组蛋白乙酰转移酶 (HAT) 的 MYST 家族,最初作为 HIV-1 TAT 相互作用蛋白被分离出来。 HAT 通过乙酰化组蛋白和非组蛋白在调节染色质重塑、转录和其他核过程中发挥重要作用。这种蛋白质是一种组蛋白乙酰化酶,在 DNA 修复和细胞凋亡中起作用,并被认为在信号转导中发挥重要作用。该基因的可变剪接导致多个转录变体。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and Apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

KAT5 基因产物(4)

mRNA Protein Name
NM_001206833.2 NP_001193762.1 histone acetyltransferase KAT5 isoform 4
NM_006388.4 NP_006379.2 histone acetyltransferase KAT5 isoform 2
NM_182709.3 NP_874368.1 histone acetyltransferase KAT5 isoform 3
NM_182710.3 NP_874369.1 histone acetyltransferase KAT5 isoform 1

KAT5 蛋白结构


Tudor-knot: RNA binding activity-knot of a chromodomain (8 - 65)


MOZ_SAS: MOZ/SAS family (286 - 475)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 513 a.a.
蛋白主名 其他名称

histone acetyltransferase KAT5

60 kDa Tat-interactive protein

重组 KAT5 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71707 KAT5 Protein, Human (His) Q92993 (E3-W513) ≥95%


疾病名称 别名
Neurodevelopmental Disorder With Dysmorphic Facies, Sleep Disturbance, And Brain Abnormalities


Genitourinary Tract Anomalies
Immune Deficiency Disease


Primary Immunodeficiency

Primary Immunodeficiency Disease

Immunologic Deficiency Syndromes


Immune Deficiency Disorder

Immunodeficiency Syndrome

Immune Disorder

Primary Immune Deficiency Disorder

Immune System Diseases

Human Immunodeficiency Virus Infection

Hiv - [Human Immunodeficiency Virus Infection]

Hiv Positive Nos

Hiv Disease

Acquired Immune Deficiency Syndrome-Related Complex

Aids-Like Syndrome

Aids-Related Complex Nos

Arc - [Aids-Related Complex]

Immunodeficiency Due To Human Immunodeficiency Virus Infection

Unspecified Human Immunodeficiency Virus Disease

Hiv Disease Nos

Human Immunodeficiency Virus Positive Nos

Hiv Nos

Deficiency Of Complement Initial Pathway

Deficiency Of Complement Terminal Pathway

Cfdd - [Complement Factor D Deficiency]

Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency

Nonfamilial Hypogammaglobulinaemia

Common Variable Immune Deficiency

Nonfamilial Agammaglobulinaemia

Common Variable Agammaglobulinaemia

Agammaglobulinaemia Nos

Agammaglobulinaemia Antibody Deficiency Syndrome

Hypogammaglobulinaemia Antibody Deficiency Syndrome

Acquired Agammaglobulinaemia Nos

Hypogammaglobulinaemia Nos

Hyper Igm

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma



Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Primary Hyperoxaluria


Hyperoxaluria, Primary


Primary Oxalosis

Congenital Oxaluria

D-Glycerate Dehydrogenase Deficiency

Glyceric Aciduria

Glycolic Aciduria

Hepatic Agt Deficiency

Oxaluria, Primary

Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency

Primary Oxaluria

Hyperoxaluria Primary

Primary Hyperoxaluria Type 2

Primary Hyperoxaluria, Type I

Chromosome 16p13.3 Deletion Syndrome, Proximal

Rubinstein-Taybi Syndrome

Broad Thumb-Hallux Syndrome

Chromosome 16p13.3 Deletion Syndrome

Rubinstein-Taybi Syndrome Due To 16p13.3 Microdeletion

Rubinstein Syndrome

Broad Thumbs-Halluces Syndrome


Rubinstein-Taybi Deletion Syndrome

Rsts Deletion Syndrome

Proximal Chromosome 16p13.3 Deletion Syndrome

16p13.3 Deletion Syndrome

Broad Thumbs And Great Toes, Characteristic Facies, And Intellectual Disability


疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma


种属 基因名 来源 基因 ID
Canis familiaris KAT5 VGNC VGNC:42211
Mus musculus KAT5 MGD MGI:1932051
Macaca mulatta KAT5 VGNC VGNC:73955
Rattus norvegicus KAT5 RGD RGD:621061
Bos taurus KAT5 VGNC VGNC:30400
Felis catus KAT5 VGNC VGNC:67665
Others KAT5 NCBI