2. Epigenetics Apoptosis
  3. Histone Acetyltransferase Apoptosis
  4. TH1834 dihydrochloride

TH1834 dihydrochloride 是一种特异性的 Tip60 (KAT5) 组蛋白乙酰转移酶抑制剂。TH1834 dihydrochloride 可诱导乳腺癌细胞凋亡并增加 DNA 损伤。TH1834 dihydrochloride 不影响相关组蛋白乙酰转移酶 MOF 的活性。抗癌活性。

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TH1834 dihydrochloride

TH1834 dihydrochloride Chemical Structure

CAS No. : 2108830-09-5

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规格 价格 是否有货
1 mg ￥670
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5 mg ￥1400
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10 mg ￥2500
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25 mg ￥5783
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TH1834 dihydrochloride 的其他形式现货产品:

Customer Review

Other Forms of TH1834 dihydrochloride:

TH1834 dihydrochloride 相关抗体

Top Publications Citing Use of Products

查看 Histone Acetyltransferase 亚型特异性产品:

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CBP/p300 GCN5/PCAF TIP60 MOZ/MORF HBO1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TH1834 dihydrochloride is a specific Tip60 (KAT5) histone acetyltransferase inhibitor. TH1834 dihydrochloride induces apoptosis and increases DNA damage in breast cancer. TH1834 dihydrochloride does not affect the activity of related histone acetyltransferase MOF. Anticancer activity[1].

IC50 & Target

TIP60

 

体外研究
(In Vitro)

TH1834 dihydrochloride 二盐酸盐 (0-500 μM；1 小时；MCF7 细胞) 处理显著降低 MCF7 细胞的活力[1]。
TH1834 dihydrochloride 二盐酸盐 (0-500 μM；1 小时；MCF7 细胞)) 处理显著增加细胞毒性[1]。
TH1834 dihydrochloride 二盐酸盐 (500 μM；1 小时；MCF7 细胞) 处理诱导 MCF7 细胞中的半胱天冬酶 3 激活[1]。
TH1834 dihydrochloride 二盐酸盐在体外显著抑制 Tip60 活性，用 TH1834 dihydrochloride 处理细胞会导致细胞凋亡并增加乳腺癌中未修复的 DNA 损伤[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TH1834 dihydrochloride 相关抗体:

Cell Viability Assay[1]

Cell Line: MCF7 cells
Concentration: 0 μM, 0.5 μM, 5 μM, 50 μM and 500 μM
Incubation Time: 1 hour
Result: Significantly reduced the viability of MCF7 cells.

Cell Cytotoxicity Assay[1]

Cell Line: MCF7 cells
Concentration: 0 μM, 0.5 μM, 5 μM, 50 μM and 500 μM
Incubation Time: 1 hour
Result: Highly significant increase in cytotoxicity at all concentrations used.

Western Blot Analysis[1]

Cell Line: MCF7 cells
Concentration: 500 μM
Incubation Time: 1 hour
Result: Marked caspase 3 activation was observed in MCF7 cells in an independent assay.
分子量

641.63

Formula

C33H42Cl2N6O3
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献

TH1834 dihydrochloride 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TH18342108830-09-5TH 1834TH-1834Histone AcetyltransferaseApoptosisHATsHATTip60DNAdamageapoptosisbreastcancerPNTcaspase-3cytotoxicityInhibitorinhibitorinhibit

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TH1834 dihydrochloride
目录号：
HY-123604A
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