1. Gene
  2. RIPK3 - receptor interacting serine/threonine kinase 3 Gene

RIPK3 - receptor interacting serine/threonine kinase 3 Gene

中文名称:受体相互作用丝氨酸/苏氨酸激酶 3

种属: Homo sapiens

同用名: RIP3

基因 ID: 11035 | 基因类型: protein coding

关于 RIPK3

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:24,336,025-24,339,991 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 245 orthologues and 23 paralogues. Broad expression in small intestine (RPKM 12.2), duodenum (RPKM 10.4) and 21 other tissues.


该基因的产物是丝氨酸/苏氨酸蛋白激酶受体相互作用蛋白 (RIP) 家族的成员,并且包含一个与其他 RIP 家族成员不同的 C 末端结构域。编码的蛋白质主要定位于细胞质,并且可以根据新的核定位和输出信号进行核质穿梭。它是肿瘤坏死因子 (TNF) 受体-I 信号复合物的组分,可诱导细胞凋亡并弱激活 NF-kappaB 转录因子。[RefSeq 提供,2008 年 7 月]

The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce Apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008]

RIPK3 基因产物(1)

mRNA Protein Name
NM_006871.4 NP_006862.2 receptor-interacting serine/threonine-protein kinase 3

RIPK3 蛋白结构


Pkinase: Protein kinase domain (22 - 280)


RHIM: RIP homotypic interaction motif (417 - 469)

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  • 518 a.a.
蛋白主名 其他名称

receptor-interacting serine/threonine-protein kinase 3


RIP-like protein kinase 3

receptor interacting protein 3

重组 RIPK3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71855 RIPK3 Protein, Human (P.pastoris, His) Q9Y572 (M1-K518) ≥95%


疾病名称 别名
Caspase 8 Deficiency

Autoimmune Lymphoproliferative Syndrome Type 2b



Caspase-8 Deficiency

Autoimmune Lymphoproliferative Syndrome, Type Iib

Alps With Recurrent Viral Infections

Autoimmune Lymphoproliferative Syndrome With Recurrent Viral Infections

Caspase 8 Deficiency Syndrome

Autoimmune Lymphoproliferative Syndrome Type Iib

Caspase Eight Deficiency State


Herpes Simplex

Herpes Simplex Infections

Herpesvirus Hominis Disease

Herpes Simplex Disease

Herpesviral Infection Due To Herpes Simplex

Infections Due To Simplex Virus

Herpes Nos

Autoimmune Lymphoproliferative Syndrome


Canale-Smith Syndrome

Autoimmune Lymphoproliferative Syndrome, Type Ia

Autoimmune Lymphoproliferative Syndrome, Type Ib

Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant


Autoimmune Lymphoproliferative Syndrome, Type 1b

Autoimmune Lymphoproliferative Syndrome, Type 1a

Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant

Fas Deficiency

Autoimmune Lymphoproliferative Syndrome 1a


Autoimmune Lymphoproliferative Syndrome Type Ia

Autoimmune Lymphoproliferative Syndrome 1b


Autoimmune Lymphoproliferative Syndrome Type Ib

Autoinflammation, Panniculitis, And Dermatosis Syndrome


Otulin-Related Autoinflammatory Syndrome



Infantile-Onset Periodic Fever-Panniculitis-Dermatosis Syndrome

Autoinflammation, Panniculitis And Dermatosis Syndrome

Otulin Deficiency

Retinal Detachment

Retinal Detachments

Rhegmatogenous Retinal Detachment

Ruptured Retina With Detachment

Retinal Hole With Detachment

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis


Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease


Amyotrophic Lateral Sclerosis, Susceptibility To


Lou Gehrig'S Disease


Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma


种属 基因名 来源 基因 ID
Felis catus RIPK3 VGNC VGNC:64642
Rattus norvegicus RIPK3 RGD RGD:628899
Mus musculus RIPK3 MGD MGI:2154952
Bos taurus RIPK3 VGNC VGNC:52818
Canis familiaris RIPK3 VGNC VGNC:110550