2. Gene
  3. Cdk5 - cyclin-dependent kinase 5 Gene

Cdk5 - cyclin-dependent kinase 5 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：细胞周期蛋白依赖性激酶 5

种属: Mus musculus

同用名: Crk6

基因 ID: 12568 | 基因类型: protein coding

关于 Cdk5

Chromosome 5: 24,623,239-24,628,528 reverse strand.GRCm39:CM000998.3

This gene has 3 transcripts (splice variants), 170 orthologues, 25 paralogues and is associated with 21 phenotypes. Ubiquitous expression in CNS E18 (RPKM 36.7), CNS E14 (RPKM 31.7) and 28 other tissues.

功能概要

该基因编码的蛋白可启动多种功能，包括 HSP90 蛋白结合活性；乙酰胆碱受体激活剂活性；和信号受体结合活性。参与调节树突棘形态发生；调节谷氨酸能突触传递；和调节蛋白质在质膜上的定位。作用于多个过程的上游或内部，包括化学突触传递；神经系统发育；和细胞内蛋白质运输的调节。位于多个细胞成分中，包括轴突；丝状足;和片状足。以多种结构表达，包括消化系统；泌尿生殖系统；肢;神经系统;和感觉器官。该基因的人类直系同源物与阿尔茨海默氏病和伴有小脑发育不全的无脑畸形 7 有关。与人 CDK5（细胞周期蛋白依赖性激酶 5）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including HSP90 protein binding activity; acetylcholine receptor activator activity; and signaling receptor binding activity. Involved in regulation of dendritic spine morphogenesis; regulation of glutamatergic synaptic transmission; and regulation of protein localization to plasma membrane. Acts upstream of or within several processes, including chemical synaptic transmission; nervous system development; and regulation of intracellular protein transport. Located in several cellular components, including axon; filopodium; and lamellipodium. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease and lissencephaly 7 with cerebellar hypoplasia. Orthologous to human CDK5 (cyclin dependent kinase 5). [provided by Alliance of Genome Resources, Apr 2022]

Cdk5 基因产物(1)

mRNA Protein Name
NM_007668.4 NP_031694.1 cyclin-dependent kinase 5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ErbB-2 class receptor binding IDA
IDA: 通过直接分析推断
11276227 MGI
enables ErbB-3 class receptor binding IDA
IDA: 通过直接分析推断
11276227 MGI
enables Hsp90 protein binding IPI
IPI: 通过物理相互作用推断
17517623 MGI
enables acetylcholine receptor activator activity IDA
IDA: 通过直接分析推断
11276227 MGI
enables p53 binding IPI
IPI: 通过物理相互作用推断
17591690 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
11276227 MGI
enables protein kinase activity IDA
IDA: 通过直接分析推断
9126296 MGI
enables protein kinase activity IMP
IMP: 通过突变表型推断
14769920 MGI
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
12941275 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within Schwann cell development IMP
IMP: 通过突变表型推断
16203963 MGI
acts upstream of or within apoptotic process IDA
IDA: 通过直接分析推断
9126296 MGI
acts upstream of or within associative learning IMP
IMP: 通过突变表型推断
11978846 MGI
acts upstream of or within axonogenesis IMP
IMP: 通过突变表型推断
11163260 MGI
acts upstream of or within behavioral response to cocaine IMP
IMP: 通过突变表型推断
18032670 MGI
acts upstream of or within calcium ion import IMP
IMP: 通过突变表型推断
18054859 MGI
acts upstream of or within cell migration IDA
IDA: 通过直接分析推断
12496365 MGI
acts upstream of or within cell migration IMP
IMP: 通过突变表型推断
17694053 MGI
acts upstream of or within cell-matrix adhesion IDA
IDA: 通过直接分析推断
12496365 MGI
acts upstream of or within central nervous system neuron development IMP
IMP: 通过突变表型推断
8855328 MGI
acts upstream of or within cerebellar cortex development IMP
IMP: 通过突变表型推断
8855328 MGI
acts upstream of or within cerebellar cortex formation IMP
IMP: 通过突变表型推断
10407039 MGI
acts upstream of or within cerebellum development IMP
IMP: 通过突变表型推断
11226314 MGI
acts upstream of or within cerebral cortex development IMP
IMP: 通过突变表型推断
9698328 MGI
acts upstream of or within corpus callosum development IMP
IMP: 通过突变表型推断
18032654 MGI
acts upstream of or within dendrite morphogenesis IMP
IMP: 通过突变表型推断
12372285 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: 通过突变表型推断
18054859 MGI
acts upstream of or within excitatory postsynaptic potential IMP
IMP: 通过突变表型推断
17529984 MGI
acts upstream of or within forebrain development IMP
IMP: 通过突变表型推断
17694053 MGI
acts upstream of or within hippocampus development IMP
IMP: 通过突变表型推断
11517264 MGI
acts upstream of or within intracellular protein transport IMP
IMP: 通过突变表型推断
8855328 MGI
acts upstream of or within layer formation in cerebral cortex IMP
IMP: 通过突变表型推断
11517264 MGI
acts upstream of or within motor neuron axon guidance IMP
IMP: 通过突变表型推断
16203963 MGI
acts upstream of or within negative regulation of axon extension IGI
IGI: 通过遗传相互作用推断
22573681 MGI
acts upstream of or within negative regulation of cell cycle IMP
IMP: 通过突变表型推断
16237170 MGI
acts upstream of or within negative regulation of protein export from nucleus IMP
IMP: 通过突变表型推断
17591690 MGI
acts upstream of or within negative regulation of protein ubiquitination IMP
IMP: 通过突变表型推断
17591690 MGI
acts upstream of or within negative regulation of synaptic plasticity IMP
IMP: 通过突变表型推断
17529984 MGI
acts upstream of or within neuron apoptotic process IMP
IMP: 通过突变表型推断
17591690 MGI
acts upstream of or within neuron differentiation IMP
IMP: 通过突变表型推断
16237170 MGI
acts upstream of or within neuron migration IMP
IMP: 通过突变表型推断
10407039 MGI
acts upstream of or within peptidyl-serine phosphorylation IDA
IDA: 通过直接分析推断
18054859 MGI
acts upstream of or within peptidyl-serine phosphorylation IMP
IMP: 通过突变表型推断
18054859 MGI
involved in peptidyl-serine phosphorylation IMP
IMP: 通过突变表型推断
24607229 MGI
acts upstream of or within peptidyl-threonine phosphorylation IDA
IDA: 通过直接分析推断
18054859 MGI
involved in peptidyl-threonine phosphorylation IMP
IMP: 通过突变表型推断
24607229 MGI
acts upstream of or within positive regulation of calcium ion-dependent exocytosis IDA
IDA: 通过直接分析推断
15123626 MGI
acts upstream of or within positive regulation of protein binding IMP
IMP: 通过突变表型推断
18054859 MGI
acts upstream of or within positive regulation of protein kinase activity IMP
IMP: 通过突变表型推断
16203963 MGI
acts upstream of or within positive regulation of protein targeting to membrane IMP
IMP: 通过突变表型推断
18054859 MGI
acts upstream of or within protein localization to synapse IMP
IMP: 通过突变表型推断
18054859 MGI
acts upstream of or within protein phosphorylation IDA
IDA: 通过直接分析推断
11517264 MGI
acts upstream of or within protein phosphorylation IGI
IGI: 通过遗传相互作用推断
17060449 MGI
acts upstream of or within protein phosphorylation IMP
IMP: 通过突变表型推断
17591690 MGI
acts upstream of or within receptor catabolic process IMP
IMP: 通过突变表型推断
17529984 MGI
acts upstream of or within receptor clustering IMP
IMP: 通过突变表型推断
16203963 MGI
acts upstream of or within regulation of cell migration IMP
IMP: 通过突变表型推断
12941275 MGI
involved in regulation of dendritic spine morphogenesis IMP
IMP: 通过突变表型推断
17143272 MGI
acts upstream of or within regulation of postsynaptic membrane potential IMP
IMP: 通过突变表型推断
16203963 MGI
involved in regulation of protein localization to plasma membrane IMP
IMP: 通过突变表型推断
24607229 MGI
involved in regulation of synaptic transmission, glutamatergic IMP
IMP: 通过突变表型推断
24607229 MGI
acts upstream of or within response to cocaine IMP
IMP: 通过突变表型推断
14769920 MGI
acts upstream of or within sensory perception of pain IMP
IMP: 通过突变表型推断
17194758 MGI
acts upstream of or within serine phosphorylation of STAT protein IDA
IDA: 通过直接分析推断
15096606 MGI
acts upstream of or within skeletal muscle tissue development IDA
IDA: 通过直接分析推断
9191048 MGI
acts upstream of or within synapse assembly IMP
IMP: 通过突变表型推断
18054859 MGI
acts upstream of or within synaptic transmission, dopaminergic IMP
IMP: 通过突变表型推断
14769920 MGI
acts upstream of or within synaptic transmission, glutamatergic IMP
IMP: 通过突变表型推断
14769920 MGI
acts upstream of or within telencephalon development IMP
IMP: 通过突变表型推断
18032654 MGI
acts upstream of or within visual learning IMP
IMP: 通过突变表型推断
17529984 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
3627430 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
3627430 MGI
located in cytosol IDA
IDA: 通过直接分析推断
9202329 MGI
located in filopodium IDA
IDA: 通过直接分析推断
12496365 MGI
located in lamellipodium IDA
IDA: 通过直接分析推断
12496365 MGI
NOT located in nucleolus IDA
IDA: 通过直接分析推断
3627430 MGI
located in nucleus IDA
IDA: 通过直接分析推断
8891282 MGI
part of protein kinase 5 complex IPI
IPI: 通过物理相互作用推断
18325333 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Cdk5 蛋白结构

STKc_CDK5

STKc_CDK5: cd07839 (2 - 285)

  • 0
  • 100
  • 200
  • 292 a.a.
蛋白主名 其他名称

cyclin-dependent kinase 5

cyclin-dependent-like kinase 5

CR6 protein kinase

TPKII catalytic subunit

cell division protein kinase 5

serine/threonine-protein kinase PSSALRE

tau protein kinase II catalytic subunit

相关产品

Approval
生物活性分子 (3)
目录号 产品名 作用方式
纯度 是否罕见病
HY-16297A Abemaciclib Inhibitor 99.97% 是
HY-10492 Dinaciclib Inhibitor 99.80% 是
HY-16297 Abemaciclib methanesulfonate Inhibitor 99.95% 是
Clinical Phase
生物活性分子 (20)
目录号 产品名 作用方式
纯度 Phase
HY-10580 GSK 3 Inhibitor IX Inhibitor 99.73% Phase 4
HY-112272A Lerociclib dihydrochloride Inhibitor 98.51% Phase 3
HY-112272 Lerociclib Inhibitor 98.35% Phase 3
HY-30237 (R)-Roscovitine Inhibitor 99.53% Phase 2
HY-103712A Samuraciclib hydrochloride Inhibitor 99.98% Phase 2
HY-50940 AT7519 Inhibitor 99.69% Phase 2
HY-137478A KB-0742 dihydrochloride Inhibitor 99.24% Phase 2
HY-X0009 Tambiciclib Inhibitor 99.21% Phase 2
HY-137478 KB-0742 Inhibitor 99.38% Phase 2
HY-103712B Samuraciclib hydrochloride dihydrate Inhibitor 99.90% Phase 2
HY-103712C Samuraciclib hydrochloride hydrate Inhibitor 99.88% Phase 2
HY-50943 AT7519 Hydrochloride Inhibitor 99.42% Phase 2
HY-103712 Samuraciclib Inhibitor 99.55% Phase 2
HY-X0009A Tambiciclib dimaleate Inhibitor / Phase 2
HY-10012 AZD-5438 Inhibitor 99.91% Phase 1
HY-12871B Atuveciclib Inhibitor 99.75% Phase 1
HY-15504 RGB-286638 Inhibitor 99.70% Phase 1
HY-11001 PHA-793887 Inhibitor 99.25% Phase 1
HY-15504A RGB-286638 free base Inhibitor 98.87% Phase 1
HY-50940A AT7519 TFA Inhibitor 96.62% Phase 1
Pre-clinical Phase
生物活性分子 (65)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12302 Kenpaullone Inhibitor 98.20% 否
HY-18340 (R)​-​CR8 Inhibitor 99.61% 否
HY-15154 NG 52 Inhibitor 99.88% 否
HY-11009 CGP60474 Inhibitor 98.90% 否
HY-18299A Purvalanol A Inhibitor 98.61% 否
HY-13461A PHA-767491 hydrochloride Inhibitor 99.49% 否
HY-10014 R547 Inhibitor 99.57% 否
HY-108359 Alsterpaullone Inhibitor 99.85% 否
HY-12280 THZ2 Inhibitor 99.03% 否
HY-18340A (R)-CR8 trihydrochloride Inhibitor 99.37% 否
HY-144117 GFB-12811 Inhibitor 98.04% 否
HY-123772 CDK5 inhibitor 20-223 Inhibitor 99.62% 否
HY-X0150 JSH-150 Inhibitor 98.66% 否
HY-119940 MC180295 Inhibitor 98.89% 否
HY-13266A BS-181 hydrochloride Inhibitor 99.93% 否
HY-18299 Purvalanol B Inhibitor 97.0% 否
HY-103221 MeBIO Inhibitor 98.0% 否
HY-145694 CDK5-IN-3 Inhibitor 99.49% 否
HY-112358 GW8510 Inhibitor 99.04% 否
HY-107419 NU6140 Inhibitor 99.07% 否
HY-13461 PHA-767491 Inhibitor 99.85% 否
HY-W011428 Olomoucine Inhibitor 99.87% 否
HY-154851 GSK-3 inhibitor 3 Inhibitor 98.72% 否
HY-117025A Manzamine A hydrochloride Inhibitor 99.66% 否
HY-155218 TMX-2172 Degrader 99.38% 否
HY-15241 NVP-LCQ195 Inhibitor 98.81% 否
HY-111930 5-Iodo-indirubin-3'-monoxime Inhibitor 99.50% 否
HY-14372 BS-194 Inhibitor 99.36% 否
HY-112403 (S)-Roscovitine Inhibitor 99.15% 否
HY-P10440 Cdk5i peptide Inhibitor 99.83% 否
HY-136726 CGP-82996 Inhibitor 98.12% 否
HY-121035 7BIO Inhibitor 99.20% 否
HY-123045 PNU-292137 Inhibitor 99.95% 否
HY-112468 PNU112455A hydrochloride Inhibitor 99.56% 否
HY-103381 NSC693868 Inhibitor 99.0% 否
HY-151069 TMX-2039 Inhibitor 99.42% 否
HY-N12625 (R)-(+)-O-Demethylbuchenavianine Inhibitor 98.67% 否
HY-103383 (R)-DRF053 dihydrochloride Inhibitor 99.30% 否
HY-119715 AG-012986 Inhibitor 99.78% 否
HY-154852 GSK-3 inhibitor 4 Inhibitor 98.77% 否
HY-13266 BS-181 Inhibitor 98.10% 否
HY-142696 CDK6/PIM1-IN-1 Inhibitor / 否
HY-139725 CDK5-IN-1 Inhibitor 98.47% 否
HY-117025 Manzamine A Inhibitor 98.2% 否
HY-114903 (E/Z)-BIO-acetoxime Inhibitor 99.0% 否
HY-151407 CDK1-IN-3 Inhibitor / 否
HY-110368 BS-181 dihydrochloride Inhibitor / 否
HY-151409 CDK1-IN-5 Inhibitor / 否
HY-178142 Multi-kinase-IN-7 Inhibitor / 否
HY-173347 BLINK11 Inhibitor / 否
HY-150641 CDK-IN-9 Inhibitor / 否
HY-137478B KB-0742 hydrochloride Inhibitor / 否
HY-164906 TMX-2138 Degrader / 否
HY-161463 CDK2-IN-28 Inhibitor / 否
HY-173348 BLINK15 Inhibitor / 否
HY-145693 CDK5-IN-2 Inhibitor / 否
HY-161595 CDK5-IN-4 Inhibitor / 否
HY-163856 CDK7-IN-30 Inhibitor / 否
HY-151878 CDK7-IN-20 Inhibitor / 否
HY-112363 Aloisine A Inhibitor / 否
HY-151408 CDK1-IN-4 Inhibitor / 否
HY-112336 Aloisine RP106 Inhibitor / 否
HY-151071 TMX-3013 Inhibitor / 否
HY-111932 Indirubin-5-sulfonate Inhibitor / 否
HY-111931 Indirubin-3'-monoxime-5-sulphonic acid Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cdk5 NCBI NCBI:1020
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