1. Gene
  2. CNR1 - cannabinoid receptor 1 Gene

CNR1 - cannabinoid receptor 1 Gene

中文名称:大麻素受体 1

种属: Homo sapiens

同用名: CB1; CNR; CB-R; CB1A; CB1R; CANN6; CB1K5

基因 ID: 1268 | 基因类型: protein coding

关于 CNR1

Cytogenetic location: 6q15 Genomic coordinates (GRCh38): 6:88,139,864-88,167,349 (from NCBI)

This gene has 7 transcripts (splice variants), 206 orthologues and 18 paralogues. Biased expression in brain (RPKM 6.2), fat (RPKM 2.7) and 12 other tissues.


该基因编码两种大麻素受体之一。大麻素,主要是 delta-9-四氢大麻酚和合成类似物,是大麻的精神活性成分。大麻素受体是鸟嘌呤核苷酸结合蛋白 (G 蛋白) 偶联受体家族的成员,其以剂量依赖性、立体选择性和百日咳毒素敏感方式抑制腺苷酸环化酶活性。已发现这两种受体参与了大麻使用者所经历的大麻素诱导的中枢神经系统效应 (包括情绪和认知的改变) 。已经为该基因描述了编码两种不同蛋白质同种型的多个转录物变体。[RefSeq 提供,2009 年 5 月]

This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit Adenylate Cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]

CNR1 基因产物(17)

mRNA Protein Name
XM_047418173.1 XP_047274129.1 cannabinoid receptor 1 isoform X1
NM_001160226.3 NP_001153698.1 cannabinoid receptor 1 isoform a
NM_001365874.3 NP_001352803.1 cannabinoid receptor 1 isoform a
NM_001365872.2 NP_001352801.1 cannabinoid receptor 1 isoform a
XM_047418171.1 XP_047274127.1 cannabinoid receptor 1 isoform X1
NM_016083.6 NP_057167.2 cannabinoid receptor 1 isoform a
XM_011535425.3 XP_011533727.1 cannabinoid receptor 1 isoform X1
NM_001160258.3 NP_001153730.1 cannabinoid receptor 1 isoform a
XM_047418172.1 XP_047274128.1 cannabinoid receptor 1 isoform X1
NM_001365869.2 NP_001352798.1 cannabinoid receptor 1 isoform a
NM_001370545.1 NP_001357474.1 cannabinoid receptor 1 isoform a
NM_001370546.1 NP_001357475.1 cannabinoid receptor 1 isoform a
NM_001370547.1 NP_001357476.1 cannabinoid receptor 1 isoform a
NM_033181.4 NP_149421.2 cannabinoid receptor 1 isoform b
NM_001365870.2 NP_001352799.1 cannabinoid receptor 1 isoform a
NM_001160259.3 NP_001153731.1 cannabinoid receptor 1 isoform a

CNR1 蛋白结构


7tm_1: 7 transmembrane receptor (rhodopsin family) (133 - 397)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 472 a.a.
蛋白主名 其他名称

cannabinoid receptor 1

cannabinoid receptor 1 (brain)

central cannabinoid receptor

重组 CNR1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P700408 CNR1 Protein-VLP, Human (HEK293, His) P21554 (M1-L472) /


疾病名称 别名
Huntington Disease

Huntington'S Disease

Huntington Chorea


Huntington'S Chorea

Huntington Chronic Progressive Hereditary Chorea

Juvenile Huntington Disease

Chronic Progressive Chorea

Chronic Progressive Hereditary Chorea

Hc - [Huntington Chorea]

Hereditary Chorea

Progressive Hereditary Chorea

Specific Developmental Disorder
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease



Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease


Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

Fragile X Syndrome


Martin-Bell Syndrome

Fraxa Syndrome

Marker X Syndrome

X-Linked Mental Retardation And Macroorchidism

Fragile X Mental Retardation Syndrome

Fra Syndrome

Mental Retardation, X-Linked, Associated With Marxq28

Frax Syndrome

Symptomatic Form Of Fragile X Syndrome In Female Carriers

Fragile-X Syndrome

Fraxe Syndrome

Anorexia Nervosa

Anorexia Nervosa, Susceptibility To


Anorexia Nervosa, Susceptibility To, 1


Anorexia Nervosa 1

An - [Anorexia Nervosa]

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia


Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial


Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia


Primary Senile Degenerative Dementia


Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1


Cerebral Angioma

Hemangioma Of Cerebrum

Cerebral Hemangioma


Epilepsy Syndrome

Epileptic Syndrome


Symptomatic Epilepsies

Post Traumatic Epilepsy

Traumatic Epilepsy

Traumatic Epileptic

Epilepsy Due To Hippocampal Sclerosis

Epilepsy With Ammon'S Horn Sclerosis

Epilepsy Due To Cortical Dysplasia

Epilepsy Due To Neuronal Migration Disorders


Postmenopausal Osteoporosis

Osteoporosis, Postmenopausal

Bone Mineral Density Quantitative Trait Locus


Osteoporosis, Involutional

Osteoporosis, Susceptibility To

Osteoporosis, Postmenopausal, Susceptibility

Bone Mineral Density Variation Qtl, Osteoporosis


Involutional Osteoporosis

Senile Osteoporosis

Osteoporosis Postmenopausal

Bone Mineral Density, Quantitative Trait Locus

Osteoporosis, Senile

Idiopathic Osteoporosis

Bone Rarefaction Nos

Type 1 Osteoporosis


Anxiety Disorder

Anxiety Disorders

Anxiety State


Anxiety Neurosis

Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2

Dravet Syndrome

Severe Myoclonic Epilepsy Of Infancy


Severe Myoclonic Epilepsy In Infancy

Epileptic Encephalopathy, Early Infantile, 6


Developmental And Epileptic Encephalopathy 6a




Developmental And Epileptic Encephalopathy 6

Early Infantile Epileptic Encephalopathy 6

Myoclonic Epilepsy, Severe, Of Infancy


Severe Myoclonus Epilepsy Of Infancy

Borderline Smei






Smei-Borderland More Than One Feature

Smei-Borderland-Myoclonic Seizures

Smei-Borderland-Spike Wave

Intractable Childhood Epilepsy With Generalized Tonic-Clonic Seizures


Developmental And Epileptic Encephalopathy, 6

Infantile Severe Myoclonic Epilepsy

Epilepsy, Intractable Childhood, With Generalized Tonic-Clonic Seizures

Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

Mood Disorder

Mood Disorders

Episodic Mood Disorder

Developmental And Epileptic Encephalopathy

Encephalopathy, Developmental And Epileptic

Lipid Metabolism Disorder


Disorder Of Fatty Acid Metabolism

Lipid Metabolism Disorders

Fatty Acid Metabolism Disorder

Disorder Of Lipid Metabolism

Abnormality Of Lipid Metabolism

Lipid Metabolism, Inborn Errors


Disorders Of Lipid Metabolism

Congenital Disorders Of Lipid Metabolism

Inherited Disorders Of Lipid Metabolism

Tobacco Addiction

Nicotine Dependence

Tobacco Addiction, Susceptibility To

Nicotine Addiction

Tobacco Use Disorder

Smoking Habit

Nicotine Dependence, Protection Against

Nicotine Addiction, Protection From

Cigarette Habituation

Cigarette Habituation, Susceptibility To

Smoking Habit, Susceptibility To

Nicotine Dependence, Susceptibility To

Nicotine Addiction, Susceptibility To

Addiction, Tobacco, Susceptibility To

Compulsive Tobacco User Syndrome

Tobacco Dependence

Tobacco Dependence Syndrome

Cigarette Addiction

Cigarette Dependence

Smoking Addiction

Smokers Syndrome

Asperger Syndrome

Asperger Disorder

Diabetes Mellitus


Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis


Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease


Amyotrophic Lateral Sclerosis, Susceptibility To


Lou Gehrig'S Disease


Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis

Substance Dependence
Body Mass Index Quantitative Trait Locus 11


Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset


Obesity Bmiq11

Obesity, Early-Onset

Obesity , Susceptibility To

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified


Cannabis Dependence

Marijuana Abuse

Cannabinoid Addiction

Cannabinoid Dependence

Cannabis Addiction

Fetal Alcohol Spectrum Disorder

Fetal Alcohol Spectrum Disorders

Fetal Alcohol Syndrome

Type 2 Diabetes Mellitus

Insulin Resistance


Diabetes Mellitus, Non-Insulin-Dependent

Type 2 Diabetes


Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes


Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]


Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes

Sveinsson Chorioretinal Atrophy


Atrophia Areata

Helicoid Peripapillary Chorioretinal Degeneration



Peripapillary Chorioretinal Degeneration, Icelandic Type

Helicoidal Peripapillary Chorioretinal Degeneration

Atrophy, Chorioretinal, Sveinsson

Eating Disorder

Eating Disorders

Feeding And Eating Disorders

Fetal Alcohol Syndrome

Fetal Alcohol Spectrum Disorders



Alcohol-Related Birth Defects

Alcohol-Related Neurodevelopmental Disorder



Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta Or Breast Milk

Alcohol Related Birth Defect

Alcohol Related Neurodevelopmental Disorder

Alcohol Affecting Fetus Or Newborn Via Placenta Or Breast Milk

Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta And/Or Breast Milk

Dysmorphism Due To Alcohol

Fetal Etoh Syndrome

Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct


Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1

Alcohol Dependence


Alcohol Dependence, Susceptibility To

Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

Alcohol Dependence, Protection Against

Alcoholism, Susceptibility To

Alcoholic Intoxication, Chronic

Pharyngeal Neoplasms

Chronic Alcoholism


Alcohol Addiction

Ethanol Dependence

Chronic Ethanolism

Chronic Alcoholic Disease Nos

Alcoholic Disease Nos


Multiple Sclerosis


Multiple Sclerosis, Susceptibility To

Disseminated Sclerosis

Multiple Sclerosis, Disease Progression, Modifier Of

Insular Sclerosis

Multiple Sclerosis Modifier Of Disease Progression

Multiple Sclerosis, Susceptibility To 1

Multiple Sclerosis, Susceptibility To, 1

Multiple Sclerosis 1

Generalized Multiple Sclerosis

Multiple Sclerosis Variant

Multiple Sclerosis Susceptibility To

Cerebrospinal Sclerosis

Generalised Multiple Sclerosis

Ms - [Multiple Sclerosis]

Disseminated Cerebrospinal Sclerosis

Disseminated Multiple Sclerosis

Disseminated Nervous System Myelosclerosis

Multiple Cerebrospinal Sclerosis

Multiple Combined Sclerosis

Multiple Sclerosis Generalised

Disseminated Brain Sclerosis

Disseminated Spinal Sclerosis

Insular Brain Sclerosis

Miliary Brain Sclerosis

Multiple Combined Sclerosis Of Spinal Cord

Multiple Ascending Sclerosis

Multiple Brain Sclerosis

Multiple Sclerosis Of Brain Stem

Multiple Sclerosis Of The Brain Stem

Multiple Sclerosis Of Cord

Sclérose En Plaques

Plaque Sclerosis

Multiple Sclerosis Of The Spinal Cord

Hallucinogen Dependence

Hallucinogen Addiction

Gilles De La Tourette Syndrome

Tourette Syndrome

Tourette Disorder



Gilles De La Tourette'S Syndrome

Motor-Verbal Tic Disorder

Guinon'S Disease

Psychogenic Tics

Tourette'S Syndrome

Chronic Motor And Vocal Tic Disorder


Tourette'S Disease

Combined Vocal And Multiple Motor Tic Disorder [De La Tourette]

Combined Vocal And Multiple Motor Tic Disorder

Tic De La Tourette

Schizophrenia 15


Schizophrenia 15 With Or Without An Affective Disorder

Schizophrenia Susceptibility Locus, Chromosome 22q13-Related

Schizophrenia Susceptibility Locus Chromosome 22q13-Related

Schizophrenia, Type 15

Psychotic Disorder

Psychotic Disorders

Mental Or Behavioural Disorder


Mental Disorders

Bulimia Nervosa


Bulimia Nervosa, Susceptibility To

Binge Eating Disorder



Hyperorexia Nervosa

Bulimia Nervosa 2


Susceptibility To Bulimia Nervosa

Bulimia Nervosa, Susceptibility To, Type 2

Bn - [Bulimia Nervosa]

Bulimia Nos



Binge Overeating

Bouts Of Overeating

Episodes Of Overeating

Lennox-Gastaut Syndrome

Epileptic Encephalopathy Lennox-Gastaut Type

Lennox Syndrome

Encephalopathy Of Childhood

Childhood Epileptic Encephalopathy With Diffuse Slow Spikes And Waves


Drug Dependence
Cannabis Abuse

Marijuana Abuse


Dystonic Disease

Dystonic Disorder

Dystonia Disorders

Neuroleptic Dyskinesia

Migraine With Or Without Aura 1


Migraine With Or Without Aura, Susceptibility To, 1

Migraine Disorder

Migraine Variant


Migraine Disorders




Migraine With Or Without Aura

Classic Migraine

Common Migraine

Disorder, Migraine

Headache Migraine

Headache Migrainous

Migraine Headache

Migraine Syndrome

Headache Including Migraine

Migraine, Susceptibility To

Chronic Pain


Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To


Dementia Praecox

Schizophrenia 1

Aids Wasting Syndrome

Hiv Wasting Syndrome

Substance Abuse

Substance-Related Disorders

Substance Abuse Problem


Acute Uvulitis

Post-Traumatic Stress Disorder


Traumatic Neurosis

Post Traumatic Stress Disorder

Stress Disorders, Post-Traumatic

Posttraumatic Stress Disorder

Ptsd - [Post Traumatic Stress Disorder]

Trauma-Related Disorders

Retinitis Pigmentosa 30


Retinitis Pigmentosa-30

Retinitis Pigmentosa, Type 30

Intraocular Pressure Quantitative Trait Locus



Glaucoma, Susceptibility To

Postinfectious Glaucoma

Glaucoma With Ocular Inflammation

Glaucoma Secondary To Eye Inflammation

Traumatic Glaucoma

Glaucoma With Concussion Of Globe

Glaucoma Due To Ocular Trauma

Glaucoma Associated With Ocular Trauma

Glaucoma Secondary To Drugs

Central Nervous System Disease


Cns Diseases

Central Nervous System Diseases

Cns Disorder

Pain Agnosia


Heroin Dependence
Withdrawal Disorder

Withdrawal Syndrome

Substance Withdrawal Syndrome



Primary Visual Agnosia

Dyspraxia Syndrome

Monomodal Visual Amnesia

Visual Amnesia

Agnosia, Primary Visual



Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder


Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder



Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma


种属 基因名 来源 基因 ID
Canis familiaris CNR1 VGNC VGNC:39426
Mus musculus CNR1 MGD MGI:104615
Macaca mulatta CNR1 VGNC VGNC:71280
Bos taurus CNR1 VGNC VGNC:27529
Rattus norvegicus CNR1 RGD RGD:2369
Others CNR1 NCBI