Cyp19a1 - cytochrome P450, family 19, subfamily a, polypeptide 1 Gene

中文名称：细胞色素 P450 ，家族 19 ，亚家族 a，多肽 1

种属: Mus musculus

同用名: Ar; ArKO; Int5; Cyp19; Int-5; p450arom

关于 Cyp19a1

功能概要

该基因编码的蛋白可启动氧化还原酶活性，作用于配对供体，结合或减少分子氧，减少黄素或黄素蛋白作为一个供体，并结合一个氧原子。在几个过程的上游或内部起作用，包括巨噬细胞趋化性的负调节；生殖结构发育；和睾酮生物合成过程。预计位于多个细胞成分中，包括树突棘；神经细胞体；和突触小泡。预计在内质网中有活性。在中枢神经系统中表达；早孕;性腺;视网膜；和胃。用于研究干燥综合征和芳香化酶过多综合征。该基因的人类直系同源物与多种疾病有关，包括芳香化酶过多综合征；膀胱颈梗阻；子宫内膜异位症（多发性）；卵巢疾病（多发性）；和前列腺疾病（多种）。与人类 CYP19A1（细胞色素 P450 家族 19 亚家族 A 成员 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Acts upstream of or within several processes, including negative regulation of macrophage chemotaxis; reproductive structure development; and testosterone biosynthetic process. Predicted to be located in several cellular components, including dendritic spine; neuronal cell body; and synaptic vesicle. Predicted to be active in endoplasmic reticulum. Is expressed in central nervous system; early conceptus; gonad; retina; and stomach. Used to study Sjogren's syndrome and aromatase excess syndrome. Human ortholog(s) of this gene implicated in several diseases, including aromatase excess syndrome; bladder neck obstruction; endometriosis (multiple); ovarian disease (multiple); and prostate disease (multiple). Orthologous to human CYP19A1 (Cytochrome P450 family 19 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]