CRHR2 - corticotropin releasing hormone receptor 2 Gene

中文名称：促肾上腺皮质激素释放激素受体 2

种属: Homo sapiens

同用名: CRF2; CRFR2; CRF-RB; HM-CRF

基因 ID: 1395 | 基因类型: protein coding

关于 CRHR2

Cytogenetic location: 7p14.3 Genomic coordinates (GRCh38): 7:30,651,942-30,700,103 (from NCBI)

This gene has 8 transcripts (splice variants), 203 orthologues and 42 paralogues. Low expression observed in reference dataset.

功能概要

该基因编码的蛋白属于 G 蛋白偶联受体 2 家族，促肾上腺皮质激素释放激素受体亚家族。该受体对促肾上腺皮质激素释放激素 (CRH) 具有高亲和力，并且还结合 CRH 相关肽，例如尿皮质素。 CRH 在下丘脑中合成，在协调对压力和免疫挑战的内分泌、自主神经和行为反应方面起着重要作用。对小鼠的研究表明，这种受体可能参与调节心血管稳态。已针对该基因描述了编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 1 月]

The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related Peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]

CRHR2 基因产物(7)

mRNA	Protein	Name
NM_001202482.2	NP_001189411.1	corticotropin-releasing factor receptor 2 isoform 4
XM_047419893.1	XP_047275849.1	corticotropin-releasing factor receptor 2 isoform X2
NM_001202475.1	NP_001189404.1	corticotropin-releasing factor receptor 2 isoform 2 precursor
NM_001202481.1	NP_001189410.1	corticotropin-releasing factor receptor 2 isoform 3
XM_047419892.1	XP_047275848.1	corticotropin-releasing factor receptor 2 isoform X1
NM_001883.5	NP_001874.2	corticotropin-releasing factor receptor 2 isoform 1
NM_001202483.2	NP_001189412.1	corticotropin-releasing factor receptor 2 isoform 5

CRHR2 蛋白结构

HRM

7tm_2

0
100
200
300
411 a.a.

蛋白主名

其他名称

corticotropin-releasing factor receptor 2

CRH-R2

关联疾病

疾病名称

别名

Borderline Personality Disorder

Anxiety

Anxiety Disorder	Anxiety Disorders
Anxiety State	Anxieties
Anxiety Neurosis

Acute Stress Disorder

Traumatic Stress Disorder	Stress Disorders, Traumatic, Acute
Stress Disorders, Traumatic

Substance Abuse

Substance-Related Disorders

Substance Abuse Problem

Panic Disorder

Panic Anxiety Syndrome	Panic
Panic Disorder 1	Episodic Paroxysmal Anxiety Disorder

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
BMIQ11	Obesity Bmiq11
Obesity, Early-Onset	Obesity , Susceptibility To
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Eating Disorder

Eating Disorders

Feeding And Eating Disorders

Generalized Anxiety Disorder

Anxiety Generalized

Colitis

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Irritable Bowel Syndrome

Irritable Colon	Psychogenic Ibs
Ibs - [Irritable Bowel Syndrome]	Spastic Bowel Syndrome

Personality Disorder

Personality Disorders	Character Disorder
Personality	Specific Personality Disorders
Enduring Personality Change After Psychiatric Illness

Cystitis

Infective Cystitis	Urocystitis
Pyocystitis

Mood Disorder

Mood Disorders

Episodic Mood Disorder

Substance Dependence

Post-Traumatic Stress Disorder

PTSD	Traumatic Neurosis
Post Traumatic Stress Disorder	Stress Disorders, Post-Traumatic
Posttraumatic Stress Disorder	Ptsd - [Post Traumatic Stress Disorder]
Trauma-Related Disorders

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P3684A	[DPro5] Corticotropin Releasing Factor, human, rat TFA	Agonist	99.71%	否
HY-RS03171	CRHR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS03172	Crhr2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS03173	Crhr2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	CRHR2	VGNC	VGNC:27709
Macaca mulatta	CRHR2	VGNC	VGNC:71492
Canis familiaris	CRHR2	VGNC	VGNC:39611
Rattus norvegicus	CRHR2	RGD	RGD:70547
Mus musculus	CRHR2	MGD	MGI:894312
Felis catus	CRHR2	VGNC	VGNC:78430

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。沪(浦)应急管危经许[2021]201709(QFYS)

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CRHR2 - corticotropin releasing hormone receptor 2 Gene

关于 CRHR2

功能概要

CRHR2 基因产物(7)

CRHR2 蛋白结构

关联疾病

直系同源

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CRHR2 - corticotropin releasing hormone receptor 2 Gene

关于 CRHR2

功能概要

CRHR2 基因产物(7)

CRHR2 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z