CSNK2A2 - casein kinase 2 alpha 2 Gene

中文名称：酪蛋白激酶 2 α 2

种属: Homo sapiens

同用名: CK2A2; CSNK2A1; CK2alpha'

基因 ID: 1459 | 基因类型: protein coding

关于 CSNK2A2

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:58,157,907-58,198,106 (from NCBI)

This gene has 8 transcripts (splice variants), 290 orthologues and 2 paralogues. Broad expression in testis (RPKM 55.0), skin (RPKM 19.3) and 24 other tissues.

功能概要

该基因编码蛋白激酶酪蛋白激酶 2 (CK2) 的 alpha' 或 alpha 2 催化亚基。酪蛋白激酶 2 是一种丝氨酸/苏氨酸蛋白激酶，可使酸性蛋白 (如酪蛋白) 磷酸化。它参与各种细胞过程，包括细胞周期控制、细胞凋亡和昼夜节律。这种异四聚体激酶包括两个催化亚基 (α 或α') 和两个调节性β 亚基。在 20 号染色体上发现了编码 alpha 或 alpha 1 亚基 (CSNK2A1，基因 ID：1457) 的密切相关基因旁系同源基因。该基因 (alpha 2) 的内含子变异可能与南亚人群的白细胞端粒长度有关。在 11 号染色体上发现了一个相关的转录假基因。[RefSeq 提供，2017 年 8 月]

This gene encodes the alpha', or alpha 2, catalytic subunit of the protein kinase Enzyme, Casein Kinase 2 (CK2). Casein Kinase 2 is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, Apoptosis, and circadian rhythms. This heterotetrameric kinase includes two catalytic subunits, either alpha or alpha', and two regulatory beta subunits. The closely related gene paralog encoding the alpha, or alpha 1 subunit (CSNK2A1, Gene ID: 1457) is found on chromosome 20. An intronic variant in this gene (alpha 2) may be associated with leukocyte telomere length in a South Asian population. A related transcribed pseudogene is found on chromosome 11. [provided by RefSeq, Aug 2017]

CSNK2A2 基因产物(1)

mRNA	Protein	Name
NM_001896.4	NP_001887.1	casein kinase II subunit alpha'

CSNK2A2 蛋白结构

Pkinase

0
100
200
300
350 a.a.

蛋白主名

其他名称

casein kinase II subunit alpha'

CK II alpha'

重组 CSNK2A2 蛋白

目录号	产品名	蛋白编号	纯度
HY-P76296	CK2 alpha/CSNK2A2 Protein, Human (sf9)	P19784 (N-G&P, M1-R350)	≥95%
HY-P76297	CK2 alpha/CSNK2A2 Protein, Human (sf9, His-GST)	P19784 (M1-R350)	≥95%

关联疾病

疾病名称

别名

Theileriasis

Theileriosis

Infection By Theileria

Spermatogenic Failure 6

Globozoospermia	SPGF6
Round-Headed Spermatozoa	Acrosome Malformation Of Spermatozoa
Spermatogenic Failure 9	Spermatozoa, Round-Headed
Globozoospermia, Complete	Globozoospermia, Total
Mae Infertility Due To Round-Headed Spermatozoa	Male Infertility Due To Globozoospermia
Male Infertility Due To Round-Headed Spermatozoa	Round-Headed Sperm Syndrome
Spgf9	Teratozoospermia

Okur-Chung Neurodevelopmental Syndrome

OCNDS

Csnk2a1-Related Neurodevelopmental Syndrome

Spermatogenic Failure 9

Male Infertility Due To Globozoospermia	SPGF9
Male Infertility Due To Round-Headed Spermatozoa	Globozoospermia, Complete
Globozoospermia, Total	Globozoospermia
Globozoospermia Syndrome	Round-Headed Sperm Syndrome
Globozoospermia Complete	Globozoospermia Total

Neonatal Leukemia

Connective Tissue Disease

Connective Tissue Diseases	Connective Tissue Disorder
Abnormality Of Connective Tissue	Disorder Of Connective Tissue
Connective Tissue Disorders

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03252	CSNK2A2 Human Pre-designed siRNA Set A		/	否
HY-163182	CSNK2A-IN-2	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	CSNK2A2	RGD	RGD:1306882
Mus musculus	CSNK2A2	MGD	MGI:88547
Canis familiaris	CSNK2A2	VGNC	VGNC:39670
Macaca mulatta	CSNK2A2	VGNC	VGNC:71524
Bos taurus	CSNK2A2	VGNC	VGNC:27769
Felis catus	CSNK2A2	VGNC	VGNC:61226
Others	CSNK2A2	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。沪(浦)应急管危经许[2021]201709(QFYS)

站点地图隐私声明

CSNK2A2 - casein kinase 2 alpha 2 Gene

关于 CSNK2A2

功能概要

CSNK2A2 基因产物(1)

CSNK2A2 蛋白结构

重组 CSNK2A2 蛋白

关联疾病

直系同源

热门区域

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CSNK2A2 - casein kinase 2 alpha 2 Gene

关于 CSNK2A2

功能概要

CSNK2A2 基因产物(1)

CSNK2A2 蛋白结构

重组 CSNK2A2 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z