1. Gene
  2. ARSK - arylsulfatase family member K Gene

ARSK - arylsulfatase family member K Gene

中文名称:芳基硫酸酯酶家族成员 K

种属: Homo sapiens

同用名: MPS10; TSULF

基因 ID: 153642 | 基因类型: protein coding

关于 ARSK

Cytogenetic location: 5q15 Genomic coordinates (GRCh38): 5:95,555,101-95,605,102 (from NCBI)

This gene has 5 transcripts (splice variants), 200 orthologues, 16 paralogues and is associated with 1 phenotype. Ubiquitous expression in thyroid (RPKM 2.9), ovary (RPKM 2.9) and 25 other tissues.

功能概要

硫酸酯酶 (EC 3.1.5.6) ,例如 ARSK,水解来自硫酸化类固醇、碳水化合物、蛋白多糖和糖脂的硫酸酯。它们参与激素生物合成、细胞信号传导调节和大分子降解 (Sardiello 等人,2005 [PubMed 16174644]) 。[OMIM 提供,2008 年 3 月]

Sulfatases (EC 3.1.5.6), such as ARSK, hydrolyze sulfate esters from sulfated Steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]

ARSK 基因产物(1)

mRNA Protein Name
NM_198150.3 NP_937793.1 arylsulfatase K precursor

ARSK 蛋白结构

Sulfatase

Sulfatase: Sulfatase (32 - 370)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 536 a.a.
蛋白主名 其他名称

arylsulfatase K

ASK

关联疾病

疾病名称 别名
Mucopolysaccharidosis, Type X

MPS10

Arsk Deficiency

Arylsulfatase K Deficiency

Mucopolysaccharidosis 10

Arlysulfatase K Deficiency

Mucopolysaccharidosis, Type 10

Gastric Dilatation

Stomach Dilatation

Metachromatic Leukodystrophy

Arylsulfatase A Deficiency

MLD

Arsa Deficiency

Sulfatide Lipidosis

Metachromatic Leukoencephalopathy

Cerebral Sclerosis, Diffuse, Metachromatic Form

Cerebroside Sulfatase Deficiency

Leukodystrophy, Metachromatic

Pseudoarylsulfatase A Deficiency

Leukodystrophy Metachromatic

Sulfatidosis

Metachromatic Leukodystrophy, Late Infantile

Metachromatic Leukodystrophy Variant

Deficiency Of Cerebroside-Sulfatase

Scholz Cerebral Sclerosis

Sulfatide Lipoidosis

Cerebral Sclerosis Diffuse Metachromatic Form

Arylsulfatase A Deficiency Disease

Cerebroside Sulphatase Deficiency Disease

Greenfield Disease

Metachromatic Leukodystrophy, Adult

Metachromatic Leukodystrophy, Juvenile

Leukodystrophy Metachromatic Adult

Leukodystrophy Metachromatic Juvenile

Leukodystrophy Metachromatic Late Infantile

Metachromatic Leukodystrophy, Adult Type

Metachromatic Leukodystrophy, Juvenile Type

Metachromatic Leukodystrophy, Infant

Greenfield'S Disease

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus ARSK MGD MGI:1924291
Bos taurus ARSK VGNC VGNC:26179
Macaca mulatta ARSK VGNC VGNC:84280
Canis familiaris ARSK VGNC VGNC:38146
Felis catus ARSK VGNC VGNC:59949
Rattus norvegicus ARSK RGD RGD:1310182