Idh1 - isocitrate dehydrogenase 1 (NADP+), soluble Gene

中文名称：异柠檬酸脱氢酶 1 (NADP+) ，可溶性

种属: Mus musculus

同用名: Id-1; Idpc; Idh-1; E030024J03Rik

关于 Idh1

功能概要

该基因编码的蛋白可启动异柠檬酸脱氢酶 (NADP+) 活性。作用于谷胱甘肽代谢过程的上游或内部；磷脂代谢过程的调节；和对氧化应激的反应。位于胞质溶胶和线粒体中。以多种结构表达，包括消化系统；泌尿生殖系统；外皮系统；神经系统;和感觉器官。该基因的人类直系同源物与自身免疫性疾病有关；血液系统癌症（多发性）；肝细胞透明细胞癌；和高级神经胶质瘤（多发）。与人类 IDH1（异柠檬酸脱氢酶 (NADP(+)) 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables isocitrate dehydrogenase (NADP+) activity. Acts upstream of or within glutathione metabolic process; regulation of phospholipid metabolic process; and response to oxidative stress. Located in cytosol and mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autoimmune disease; hematologic Cancer (multiple); hepatocellular clear cell carcinoma; and high grade glioma (multiple). Orthologous to human IDH1 (isocitrate dehydrogenase (NADP(+)) 1). [provided by Alliance of Genome Resources, Apr 2022]