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  2. Mmp10 - matrix metallopeptidase 10 Gene

Mmp10 - matrix metallopeptidase 10 Gene

中文名称:基质金属肽酶 10

种属: Mus musculus

同用名: SL-2; MMP-10

基因 ID: 17384 | 基因类型: protein coding

关于 Mmp10

Chromosome 9: 7,502,353-7,510,241 forward strand.GRCm39:CM001002.3

This gene has 1 transcript (splice variant), 417 orthologues, 23 paralogues and is associated with 4 phenotypes. Biased expression in large intestine adult (RPKM 4.9), duodenum adult (RPKM 2.4) and 2 other tissues.

功能概要

该基因编码细胞外基质降解酶基质金属蛋白酶家族的一个成员,这些酶参与组织重塑、伤口修复、动脉粥样硬化进展和肿瘤侵袭。编码的前原蛋白经过蛋白水解加工,产生成熟的锌依赖性内肽酶。小鼠体内编码蛋白的缺乏促进了实验性肺癌的形成,加剧了实验性结肠炎并促进了与炎症相关的结肠发育不良的发展。该基因位于 9 号染色体上的其他基质金属蛋白酶基因簇中。[RefSeq 提供,2016 年 2 月]

This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase Enzyme. The lack of encoded protein in mice promotes experimental lung Cancer formation, exacerbates experimental colitis and promotes development of inflammation-associated colonic dysplasia. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016]

Mmp10 基因产物(1)

mRNA Protein Name
NM_019471.3 NP_062344.1 stromelysin-2 preproprotein

Mmp10 蛋白结构

PG_binding_1

PG_binding_1: pfam01471 (32 - 86)

Peptidase_M10

Peptidase_M10: pfam00413 (107 - 263)

HX

HX: cd00094 (285 - 475)

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  • 476 a.a.
蛋白主名 其他名称

stromelysin-2

matrix metalloproteinase 10

transin-2

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mmp10 NCBI NCBI:4319