Cgas - cyclic GMP-AMP synthase Gene

中文名称：环状 GMP-AMP 合酶

种属: Mus musculus

同用名: Mb21d1; E330016A19Rik

关于 Cgas

功能概要

由该基因编码的蛋白质是一种 DNA 结合胞质蛋白，在检测到细胞质中存在 DNA 后，它会催化环磷酸鸟苷-磷酸腺苷 (cGAMP) 的合成。 cGAMP 结合另一种蛋白质，干扰素基因刺激物 (STING)，导致干扰素的诱导和宿主免疫反应。在存在某些病毒感染的情况下，该基因的表达减少会抑制干扰素的诱导。可变剪接导致多个转录本变体。 [RefSeq 提供，2014 年 7 月]

The protein encoded by this gene is a DNA binding cytosolic protein that catalyzes the synthesis of cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) after sensing the presence of DNA in the cytoplasm. cGAMP binds another protein, Stimulator of interferon genes (STING), leading to the induction of interferons, and a host immune response. Reduced expression of this gene inhibits interferon induction in the presence of some viral infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]