2. Gene
  3. DAPK2 - death associated protein kinase 2 Gene

DAPK2 - death associated protein kinase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：死亡相关蛋白激酶 2

种属: Homo sapiens

同用名: DRP1; DRP-1

基因 ID: 23604 | 基因类型: protein coding

关于 DAPK2

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:63,907,036-64,046,485 (from NCBI)

This gene has 13 transcripts (splice variants), 202 orthologues and 4 paralogues. Broad expression in thyroid (RPKM 7.0), lung (RPKM 4.4) and 18 other tissues.

功能概要

该基因编码一种属于丝氨酸/苏氨酸蛋白激酶家族的蛋白质。该蛋白质包含一个 N 末端蛋白激酶结构域，后跟一个保守的钙调蛋白结合结构域，与死亡相关蛋白激酶 1 (DAPK1) 具有显着相似性，DAPK1 是程序性细胞死亡的正调节因子。该基因的过表达显示诱导细胞凋亡。它使用多个聚腺苷酸化位点。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell Apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008]

DAPK2 基因产物(20)

mRNA Protein Name
NM_001363730.2 NP_001350659.1 death-associated protein kinase 2 isoform 2
NM_001384997.1 NP_001371926.1 death-associated protein kinase 2 isoform 3
NM_001384998.1 NP_001371927.1 death-associated protein kinase 2 isoform 4
NM_001384999.1 NP_001371928.1 death-associated protein kinase 2 isoform 5
NM_001385000.1 NP_001371929.1 death-associated protein kinase 2 isoform 6
NM_001395279.1 NP_001382208.1 death-associated protein kinase 2 isoform 7
NM_001395281.1 NP_001382210.1 death-associated protein kinase 2 isoform 8
NM_001395282.1 NP_001382211.1 death-associated protein kinase 2 isoform 4
NM_001395283.1 NP_001382212.1 death-associated protein kinase 2 isoform 8
NM_001395284.1 NP_001382213.1 death-associated protein kinase 2 isoform 9
NM_001395285.1 NP_001382214.1 death-associated protein kinase 2 isoform 10
NM_001395286.1 NP_001382215.1 death-associated protein kinase 2 isoform 11
NM_001395287.1 NP_001382216.1 death-associated protein kinase 2 isoform 11
NM_001395288.1 NP_001382217.1 death-associated protein kinase 2 isoform 12
NM_001395289.1 NP_001382218.1 death-associated protein kinase 2 isoform 9
NM_001395290.1 NP_001382219.1 death-associated protein kinase 2 isoform 13 precursor
NM_001395291.1 NP_001382220.1 death-associated protein kinase 2 isoform 14
NM_001395292.1 NP_001382221.1 death-associated protein kinase 2 isoform 9
NM_001395293.1 NP_001382222.1 death-associated protein kinase 2 isoform 15
NM_014326.5 NP_055141.2 death-associated protein kinase 2 isoform 1

DAPK2 蛋白结构

Pkinase

Pkinase: Protein kinase domain (23 - 285)

  • 0
  • 100
  • 200
  • 300
  • 370 a.a.
蛋白主名 其他名称

death-associated protein kinase 2

DAP kinase 2

关联疾病

疾病名称 别名
Charcot-Marie-Tooth Disease Type 2a2b

Severe Early-Onset Axonal Neuropathy Due To Mfn2 Deficiency

Ar-Cmt2, Ouvrier Type

Autosomal Recessive Charcot-Marie-Tooth Disease, Ouvrier Type

Seoan Due To Mfn2 Deficiency

Charcot-Marie-Tooth Disease, Axonal, Type 2a2b

Cmt2a2b

Charcot-Marie-Tooth Disease, Type 2a2b
Bladder Cancer

Urinary Bladder Cancer

Bladder Carcinoma

Urinary Bladder Carcinoma

Bladder Neoplasm

Bladder Tumor

Cancer, Bladder

Malignant Neoplasm Of Urinary Bladder

Carcinoma Of Bladder

Bladder Cancer, Somatic

Tumor Of The Bladder

Carcinoma Of Urinary Bladder

Bladder Carcinoma Urinary

Cancer Of The Urinary Bladder

Cancer, Urinary Bladder

Malignant Bladder Neoplasm

Malignant Bladder Tumor

Neoplasm Of The Bladder

Neoplasm Of The Urinary Bladder

Tumor Of The Urinary Bladder

Urinary Bladder Neoplasm

BLC

Urothelial Carcinoma Of The Bladder

Bladder Tumors

Urinary Bladder Neoplasms

Bladder Cancer Nos

Vesical Cancer Nos

Malignant Neoplasm Of Bladder, Part Unspecified

Malignant Tumour Of Urinary Bladder

Primary Malignant Neoplasm Of Bladder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-131909 CJ-2360 Inhibitor / 否
HY-RS03528 DAPK2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus DAPK2 VGNC VGNC:55109
Felis catus DAPK2 VGNC VGNC:80992
Macaca mulatta DAPK2 VGNC VGNC:71733
Mus musculus DAPK2 MGD MGI:1341297
Canis familiaris DAPK2 VGNC VGNC:59108
Rattus norvegicus DAPK2 RGD RGD:1304708
Others DAPK2 NCBI
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