2. Gene
  3. MAP3K15 - mitogen-activated protein kinase kinase kinase 15 Gene

MAP3K15 - mitogen-activated protein kinase kinase kinase 15 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：丝裂原活化蛋白激酶激酶 15

种属: Homo sapiens

同用名: ASK3; bA723P2.3

基因 ID: 389840 | 基因类型: protein coding

关于 MAP3K15

Cytogenetic location: Xp22.12 Genomic coordinates (GRCh38): X:19,360,059-19,515,508 (from NCBI)

This gene has 4 transcripts (splice variants), 195 orthologues and 2 paralogues. Ubiquitous expression in adrenal (RPKM 7.5), heart (RPKM 3.2) and 24 other tissues.

功能概要

该基因编码的蛋白质是丝裂原活化蛋白激酶 (MAPK) 家族的成员。这些家族成员在蛋白激酶信号转导级联中发挥作用，其中激活的 MAPK 激酶激酶 (MAP3K) 磷酸化并激活特定的 MAPK 激酶 (MAP2K) ，然后激活特定的 MAPK。这种 MAP3K 蛋白在细胞应激引发的凋亡细胞死亡中起着重要作用。[RefSeq 提供，2010 年 7 月]

The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members function in a protein kinase signal transduction cascade, where an activated MAPK kinase kinase (MAP3K) phosphorylates and activates a specific MAPK kinase (MAP2K), which then activates a specific MAPK. This MAP3K protein plays an essential role in apoptotic cell death triggered by cellular stresses. [provided by RefSeq, Jul 2010]

MAP3K15 基因产物(1)

mRNA Protein Name
NM_001001671.4 NP_001001671.3 mitogen-activated protein kinase kinase kinase 15

MAP3K15 蛋白结构

DUF4071

DUF4071: Domain of unknown function (DUF4071) (136 - 514)

Pkinase

Pkinase: Protein kinase domain (657 - 907)

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  • 1313 a.a.
蛋白主名 其他名称

mitogen-activated protein kinase kinase kinase 15

MAPK/ERK kinase kinase 15

关联疾病

疾病名称 别名
Neuropathy, Hereditary Sensory And Autonomic, Type Iia

Hereditary Sensory And Autonomic Neuropathy Type 2

Hsan2

HSAN2A

Morvan Disease

Hereditary Sensory And Autonomic Neuropathy Type Ii

Neurogenic Acroosteolysis

Hsan Iia

Hsn2a

Hsn Iia

Neuropathy, Progressive Sensory, Of Children

Neuropathy, Congenital Sensory

Neuropathy, Hereditary Sensory And Autonomic, Type Ii

Hereditary Sensory And Autonomic Neuropathy Type 2a

Hereditary Sensory And Autonomic Neuropathy Type Iia

Hsanii

Congenital Sensory Neuropathy

Hsan Type Ii

Morvan Syndrome

Neuropathy, Hereditary Sensory And Autonomic, Type 2a

Morvan'S Disease

Neuropathy, Hereditary Sensory, Type Iia

Acroosteolysis, Neurogenic

Acroosteolysis, Giaccai Type

Neuropathy, Hereditary Sensory Radicular, Autosomal Recessive

Hereditary Sensory Autonomic Neuropathy Type 2

Giaccai Type Acroosteolysis

Hereditary Sensory Neuropathy Type 2

Hereditary Sensory Radicular Neuropathy, Recessive Form

Hsan2b

Hsan2c

Hsan2d

Hsn Type Ii

Autosomal Recessive Sensory Radicular Neuropathy

Limbic Encephalitis-Neuromyotonia-Hyperhidrosis-Polyneuropathy Syndrome

Morvan Fibrillary Chorea

Neuropathy, Hereditary Sensory And Autonomic, 2a

Acroosteolysis Giaccai Type

Hereditary Sensory Neuropathy Type Iia

Hereditary Sensory Radicular Neuropathy Autosomal Recessive

Progressive Sensory Neuropathy Of Children

Neuropathy Congenital Sensory

Charcot-Marie-Tooth Disease

Neuropathy, Sensory And Autonomic, Hereditary, Type Iia

Hereditary Sensory Autonomic Neuropathy, Type 2

Hereditary Motor And Sensory-Neuropathy Type Ii

Sensory Neuropathy, Hereditary

Neuropathy, Hereditary Sensory And Autonomic, Type Iib
Martin-Probst Syndrome

Deafness-Intellectual Disability, Martin-Probst Type Syndrome

Martin-Probst Deafness-Mental Retardation Syndrome

Mental Retardation, X-Linked, Syndromic, Martin-Probst Type

MRXSMP

Deafness-Intellectual Disability Syndrome, Martin-Probst Type

Hearing Loss-Intellectual Disability Syndrome, Martin-Probst Type

X-Linked Deafness-Intellectual Disability Syndrome Syndrome

X-Linked Hearing Loss-Intellectual Disability Syndrome Syndrome
Large Congenital Melanocytic Nevus

Giant Pigmented Hairy Nevus

Giant Congenital Melanocytic Nevus

Gmn

Congenital Pigmented Nevus

Lcmn

Gphn

Giant Congenital Nevus

Bathing Trunk Nevus

Congenital Giant Pigmented Nevus

Congenital Hairy Nevus

Giant Hairy Nevus

Giant Pigmented Nevus

Congenital Giant Pigmented Nevus Of Skin

Congenital Melanocytic Nevus Syndrome

Giant Congenital Melanocytic Nevi

Giant Congenital Pigmented Nevus

Melanocytic Nevus Syndrome, Congenital
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08052 MAP3K15 Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus MAP3K15 VGNC VGNC:63377
Mus musculus MAP3K15 MGD MGI:2448588
Bos taurus MAP3K15 VGNC VGNC:31193
Canis familiaris MAP3K15 VGNC VGNC:42971
Rattus norvegicus MAP3K15 RGD RGD:1560603
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