2. Gene
  3. MAP3K10 - mitogen-activated protein kinase kinase kinase 10 Gene

MAP3K10 - mitogen-activated protein kinase kinase kinase 10 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：丝裂原活化蛋白激酶激酶 10

种属: Homo sapiens

同用名: MST; MLK2; MEKK10

基因 ID: 4294 | 基因类型: protein coding

关于 MAP3K10

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:40,191,426-40,215,575 (from NCBI)

This gene has 8 transcripts (splice variants), 186 orthologues and 23 paralogues. Broad expression in brain (RPKM 11.1), testis (RPKM 4.1) and 24 other tissues.

功能概要

该基因编码的蛋白质是丝氨酸/苏氨酸激酶家族的成员。这种激酶已被证明可以激活 MAPK8/JNK 和 MKK4/SEK1，并且这种激酶本身可以被磷酸化，从而被 JNK 激酶激活。该激酶优先在 JNK 信号通路上发挥作用，据报道参与神经生长因子 (NGF) 诱导的神经细胞凋亡。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal Apoptosis. [provided by RefSeq, Jul 2008]

MAP3K10 基因产物(1)

mRNA Protein Name
NM_002446.4 NP_002437.2 mitogen-activated protein kinase kinase kinase 10

MAP3K10 蛋白结构

SH3_9

SH3_9: Variant SH3 domain (23 - 77)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (98 - 357)

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  • 954 a.a.
蛋白主名 其他名称

mitogen-activated protein kinase kinase kinase 10

MKN28 derived nonreceptor_type serine/threonine kinase

关联疾病

疾病名称 别名
Cardiofaciocutaneous Syndrome 1

Cardiofaciocutaneous Syndrome

Cfc Syndrome

Cardio-Facio-Cutaneous Syndrome

CFC1

Cfcs

Cardio-Facial-Cutaneous Syndrome

Congenital Heart Defects Characteristic Facial Appearance Ectodermal Abnormalities And Growth Failure

Cardiofaciocutaneous Syndrome, Type 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08047 MAP3K10 Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus MAP3K10 VGNC VGNC:68154
Mus musculus MAP3K10 MGD MGI:1346879
Macaca mulatta MAP3K10 VGNC VGNC:74492
Bos taurus MAP3K10 VGNC VGNC:57052
Rattus norvegicus MAP3K10 RGD RGD:1308381
Canis familiaris MAP3K10 VGNC VGNC:53748
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