2. Gene
  3. Gne - glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase Gene

Gne - glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: NM; DMRV; IBM2; Uae1; GLCNE; 2310066H07Rik

基因 ID: 50798 | 基因类型: protein coding

关于 Gne

功能概要

Predicted to enable N-acylmannosamine kinase activity and UDP-N-acetylglucosamine 2-epimerase activity. Predicted to be involved in UDP-N-acetylglucosamine metabolic process. Predicted to act upstream of or within N-acetylneuraminate metabolic process. Predicted to be located in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and respiratory system. Human ortholog(s) of this gene implicated in GNE myopathy and sialuria. Orthologous to human GNE (glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Gne 基因产物(3)

mRNA Protein Name
NM_001190414.2 NP_001177343.1 bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform 1
NM_001357539.1 NP_001344468.1 bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform 3
NM_015828.3 NP_056643.3 bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables N-acylmannosamine kinase activity IMP
IMP: 通过突变表型推断
38237079 MGI
enables UDP-N-acetylglucosamine 2-epimerase activity IDA
IDA: 通过直接分析推断
10745088 MGI
enables UDP-N-acetylglucosamine 2-epimerase activity IMP
IMP: 通过突变表型推断
11929971 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in N-acetylneuraminate biosynthetic process IMP
IMP: 通过突变表型推断
11929971 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytosol IDA
IDA: 通过直接分析推断
10745088 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

UDP-GlcNAc-2-epimerase/ManAc kinase

UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-13246 Apitolisib 99.29% Phase 2
HY-128850 N-Acetyl-D-mannosamine 99.99% Phase 2
Pre-clinical Phase
生物活性分子 (83)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100742A (R)-GNE-140 Inhibitor 99.73% 否
HY-147214 GNE-7883 Inhibitor 99.54% 否
HY-100343 GNE-495 Inhibitor 99.49% 否
HY-108696 GNE-781 Inhibitor 98.16% 否
HY-12947 GNE-3511 Inhibitor 99.54% 否
HY-108435 GNE-049 Inhibitor 98.01% 否
HY-107986 GNE-6776 Inhibitor 98.03% 否
HY-129937A GNE-987 Inhibitor 99.98% 否
HY-15796 GNE0877 Inhibitor 99.81% 否
HY-15766 GNE-617 Inhibitor 99.58% 否
HY-12632 GNE 2861 Inhibitor 99.16% 否
HY-18163 GNE-7915 Inhibitor 99.82% 否
HY-112937 GNE-6640 Inhibitor 99.91% 否
HY-100726 GNE-272 Inhibitor 99.60% 否
HY-100742 GNE-140 racemate Inhibitor 99.38% 否
HY-120028 GNE-207 Inhibitor 99.94% 否
HY-154984 JET-209 Degrader 98.07% 否
HY-149026 GNE-064 Inhibitor 99.65% 否
HY-12763 GNE-317 Inhibitor 98.76% 否
HY-158113 CBPD-409 Degrader 99.38% 否
HY-107409 GNE 5729 Agonist 99.50% 否
HY-145341 GNE-149 Antagonist 99.18% 否
HY-10811 GNE-493 Inhibitor 99.81% 否
HY-112803 GNE-371 98.21% 否
HY-129939 PROTAC BRD4 ligand-1 Inhibitor 99.85% 否
HY-114332 GNE-8505 Inhibitor 99.86% 否
HY-133736 PROTAC BRD4 Degrader-5-CO-PEG3-N3 99.73% 否
HY-19775 GNE-6468 Antagonist 98.02% 否
HY-12628 GNE-618 Inhibitor 99.89% 否
HY-135892 GNE-1858 Inhibitor 99.23% 否
HY-100742B (S)-GNE-140 Inhibitor 99.07% 否
HY-123621 GNE-375 Inhibitor 99.93% 否
HY-11042 GNE-477 Inhibitor 98.75% 否
HY-129938 PROTAC BRD4 Degrader-24 99.61% 否
HY-12282 GNE-9605 Inhibitor 99.51% 否
HY-129527 GNE-9278 Modulator 99.91% 否
HY-15883 GNE-900 99.21% 否
HY-142160 GNE-9815 Inhibitor 98.94% 否
HY-U00428A GNE 220 hydrochloride Inhibitor 98.22% 否
HY-12410 GNE-9822 Inhibitor 98.47% 否
HY-141551 GNE-274 Degrader 98.00% 否
HY-150289 GNE-235 98.45% 否
HY-112279 GNE-131 Inhibitor 98.15% 否
HY-149056 GNE-6893 Inhibitor 99.94% 否
HY-18163A GNE-7915 tosylate Inhibitor 99.06% 否
HY-117865 GNE-886 Inhibitor 99.81% 否
HY-10812 GNE-490 Inhibitor 96.29% 否
HY-108337 GNE-0723 Agonist 98.74% 否
HY-19774 GNE-0946 Inhibitor 98.09% 否
HY-123824 GNE-0439 Inhibitor 99.80% 否
HY-15766A GNE-617 hydrochloride Inhibitor 99.16% 否
HY-162553 GNE7599 / 否
HY-134592 Piperidine-GNE-049-N-Boc 98.48% 否
HY-107498 GNE-8324 Modulator 98.88% 否
HY-149056A (3S,4R)-GNE-6893 Inhibitor 99.49% 否
HY-16983 GNE-3500 Antagonist 98.90% 否
HY-RS05551 GNE Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-U00428 GNE 220 Inhibitor / 否
HY-126291 GNE-616 Inhibitor / 否
HY-128850S1 N-Acetyl-D-mannosamine-13C 99.84% 否
HY-132294 GNE-502 Inhibitor 99.73% 否
HY-128585 GNE684 Inhibitor / 否
HY-107409B (S,S)-GNE 5729 99.65% 否
HY-107423 GNE 6901 Agonist 99.31% 否
HY-124153 GNE-431 Inhibitor / 否
HY-128850S2 N-Acetyl-D-mannosamine-13C-1 / 否
HY-128850S5 N-Acetyl-D-mannosamine-15N / 否
HY-129937 (S)-GNE-987 Inhibitor / 否
HY-132294A (1S,3R)-GNE-502 Inhibitor / 否
HY-13847 GNE-555 Inhibitor / 否
HY-141551B (R)-GNE-274 / 否
HY-148238 GNE-2256 Inhibitor / 否
HY-15882 GNE-783 / 否
HY-174261 KRAS-IN-5 Inhibitor / 否
HY-175448 GNE-1567 / 否
HY-175449 XIAP ligand 5 Antagonist / 否
HY-175450 XIAP ligand-Linker Conjugate 2 Antagonist / 否
HY-176783 GNE-5152 Inhibitor / 否
HY-12517 GNE-293 Inhibitor / 否
HY-RS16774 Gne Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23214 Gne Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-101783 GNE-955 Inhibitor / 否
HY-16984 GNE-4997 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gne NCBI NCBI:10020
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