Nr1h4 - nuclear receptor subfamily 1, group H, member 4 Gene

中文名称：核受体亚家族 1 ，H 组，成员 4

种属: Rattus norvegicus

同用名: Fxr

关于 Nr1h4

功能概要

该基因编码的蛋白可启动多种功能，包括 DNA 结合转录因子活性、RNA 聚合酶 II 特异性；胆汁酸受体活性；和鹅脱氧胆酸结合活性。有助于双链 DNA 结合活性。参与多个过程，包括脂质稳态；肝脏发育；和生物合成过程的负调控。位于核内。受体复合体的一部分。用于研究肝外胆汁淤积；肝内胆汁淤积；和门静脉高压症。胆管疾病的生物标志物（多种）；肝病（多发性）；非酒精性脂肪肝（多发性）；肥胖;和提前绝经。该基因的人类直系同源物与肝外胆汁淤积有关；肝细胞癌；和进行性家族性肝内胆汁淤积症 5。与人类 NR1H4 同源（核受体亚家族 1 H 组成员 4）。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; bile acid receptor activity; and chenodeoxycholic acid binding activity. Contributes to double-stranded DNA binding activity. Involved in several processes, including lipid homeostasis; liver development; and negative regulation of biosynthetic process. Located in nucleus. Part of receptor complex. Used to study extrahepatic cholestasis; intrahepatic cholestasis; and portal hypertension. Biomarker of bile duct disease (multiple); liver disease (multiple); non-alcoholic fatty liver disease (multiple); obesity; and premature menopause. Human ortholog(s) of this gene implicated in extrahepatic cholestasis; hepatocellular carcinoma; and progressive familial intrahepatic cholestasis 5. Orthologous to human NR1H4 (nuclear receptor subfamily 1 group H member 4). [provided by Alliance of Genome Resources, Apr 2022]