ASIC3 - acid sensing ion channel subunit 3 Gene

中文名称：酸感应离子通道亚基 3

种属: Homo sapiens

同用名: ACCN3; TNaC1; DRASIC; SLNAC1

基因 ID: 9311 | 基因类型: protein coding

关于 ASIC3

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:151,048,292-151,052,756 (from NCBI)

This gene has 9 transcripts (splice variants), 117 orthologues and 8 paralogues. Broad expression in testis (RPKM 3.0), brain (RPKM 2.0) and 20 other tissues.

功能概要

该基因编码退化蛋白/上皮钠通道 (DEG/ENaC) 超家族的成员。该家族的成员是阿米洛利敏感的钠通道，包含细胞内 N 和 C 末端、两个疏水跨膜区域和一个大的细胞外环，其中有许多具有保守间距的半胱氨酸残基。由该基因编码的成员是酸传感器，可能在检测持久的 pH 变化中发挥重要作用。此外，该成员与酸敏感 (质子门控) 离子通道 2 之间的异聚结合已被观察为对钆敏感的质子门控通道。已经描述了选择性剪接的转录物变体。[RefSeq 提供，2012 年 2 月]

This gene encodes a member of the degenerin/epithelial Sodium Channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]

ASIC3 基因产物(3)

mRNA	Protein	Name
NM_004769.4	NP_004760.1	acid-sensing ion channel 3 isoform a
NM_020321.3	NP_064717.1	acid-sensing ion channel 3 isoform b
NM_020322.3	NP_064718.1	acid-sensing ion channel 3 isoform c

ASIC3 蛋白结构

ASC

0
100
200
300
400
500
531 a.a.

蛋白主名

其他名称

acid-sensing ion channel 3

acid sensing (proton gated) ion channel 3

关联疾病

疾病名称

别名

Acute Salpingo-Oophoritis

Acute Salpingitis And Oophoritis

Frozen Shoulder

Adhesive Capsulitis Of Shoulder	Bursitis
Adhesions-Capsulitis,Shoulder	Pericapsulitis Of Shoulder
Duplay Bursitis	Adhesive Shoulder Peritendinitis
Subscapular Adhesion	Shoulder Adhesion
Adhesive Enthesopathy Of Shoulder Region	Adhesive Peritendinitis
Adhesive Shoulder Tenosynovitis	Duplay Periarthritis
Adhesive Shoulder Tendinitis

Femoral Cancer

Femoral Neoplasms	Cancer Of The Femur
Femoral Neoplasm	Neoplasm Of Femur

Myofascial Pain Syndrome

Myofascial Pain Syndromes	Myofascial Pain Dysfunction Syndrome
Fibromyalgia

Miliaria Rubra

Miliaria	Prickly Heat
Miliaria Crystallina

Complex Regional Pain Syndrome

Complex Regional Pain Syndromes	Reflex Sympathetic Dystrophy
Crps

Somatoform Disorder

Physiological Malfunction Arising From Mental Factor	Psychosomatic Disorder
Psychophysiologic Disorders

Paine Syndrome

Pain Disorder	Pain
Microcephaly With Spastic Diplegia	Pain Syndrome

Paroxysmal Extreme Pain Disorder

PEPD	Familial Rectal Pain
Pexpd	Submandibular, Ocular, And Rectal Pain With Flushing
Pain, Submandibular, Ocular, And Rectal, With Flushing	Rectal Pain, Familial
Submandibular, Ocular And Rectal Pain With Flushing	Familial Rectal Syndrome
Frp	Pain Disorder, Paroxysmal, Extreme

Chronic Fatigue Syndrome

Myalgic Encephalomyelitis	Postviral Fatigue Syndrome
Cfs	Myalgic Encephalitis
Encephalomyelitis, Myalgic	Chronic Fatigue
Fatigue Syndrome, Chronic	Benign Myalgic Encephalomyelitis
Akureyri	Akureyri Disease
Cfs - [Chronic Fatigue Syndrome]	Epidemic Neuromyasthenia
Myalgic Encephalomyelitis Syndrome	Me - [Myalgic Encephalomyelitis]
Pvfs - [Postviral Fatigue Syndrome]	Neuromyasthenia
Iceland Disease	Icelandic Disease

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-107757	GMQ	Activator	99.69%	否
HY-122135	A-317567	Inhibitor	99.38%	否
HY-131879	NS383		99.83%	否
HY-P1346A	APETx2 TFA	Inhibitor	98.38%	否
HY-P1346	APETx2	Inhibitor	/	否
HY-100939	4-Chlorophenylguanidine hydrochloride	Modulator	99.07%	否
HY-155017	6-Iodoamiloride	Inhibitor	/	否
HY-P1249	Neuropeptide SF(mouse,rat)	Agonist	/	否
HY-P1249A	Neuropeptide SF(mouse,rat) TFA	Agonist	/	否
HY-P1441A	Mambalgin 1 TFA	Inhibitor	/	否
HY-RS01091	ASIC3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	ASIC3	VGNC	VGNC:38179
Bos taurus	ASIC3	VGNC	VGNC:26212
Felis catus	ASIC3	VGNC	VGNC:59972
Macaca mulatta	ASIC3	VGNC	VGNC:80797
Rattus norvegicus	ASIC3	RGD	RGD:708578
Mus musculus	ASIC3	MGD	MGI:2159339

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。沪(浦)应急管危经许[2021]201709(QFYS)

站点地图隐私声明

ASIC3 - acid sensing ion channel subunit 3 Gene

关于 ASIC3

功能概要

ASIC3 基因产物(3)

ASIC3 蛋白结构

关联疾病

直系同源

热门区域

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ASIC3 - acid sensing ion channel subunit 3 Gene

关于 ASIC3

功能概要

ASIC3 基因产物(3)

ASIC3 蛋白结构

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

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