CAMK2N2 - calcium/calmodulin dependent protein kinase II inhibitor 2 Gene

中文名称：钙/钙调蛋白依赖性蛋白激酶 II 抑制因子 2

种属: Homo sapiens

同用名: CAMKIIN; CAM-KIIN

关于 CAMK2N2

功能概要

该基因编码的蛋白质与大鼠 CaM-KII 抑制蛋白高度相似，后者是钙/钙调蛋白依赖性蛋白激酶 II (CAMKII) 的抑制剂。 CAMKII 调节多种生理功能，包括通过磷酸化 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate (AMPA) 受体的神经元突触可塑性。对大鼠中类似蛋白质的研究表明，该蛋白质可能作为 CaM-KII 的负调节剂发挥作用，并可能起到抑制 AMPA 受体磷酸化的作用。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein that is highly similar to the rat CaM-KII inhibitory protein, an inhibitor of calcium/calmodulin-dependent protein kinase II (CAMKII). CAMKII regulates numerous physiological functions, including neuronal synaptic plasticity through the phosphorylation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate (AMPA) receptors. Studies of the similar protein in rat suggest that this protein may function as a negative regulator of CaM-KII and may act to inhibit the phosphorylation of AMPA receptors. [provided by RefSeq, Jul 2008]