2. Metabolic Enzyme/Protease
  3. Glucokinase
  4. GKA50

GKA50 是一种有效的葡萄糖激酶 (glucokinase) 激活剂 (EC50=33 nM)。GKA50 刺激小鼠胰岛分泌胰岛素。GKA50 是啮齿动物和人类胰岛中 β 细胞代谢的葡萄糖样激活剂，以及 Ca2+ 依赖性胰岛素分泌调节剂。GKA50对高脂喂养的雌性大鼠血糖有显著的降低作用。

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GKA50 Chemical Structure

GKA50 Chemical Structure

CAS No. : 851884-87-2

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1635
In-stock
1 mg ￥650
In-stock
5 mg ￥1600
In-stock
10 mg ￥2480
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of GKA50:

GKA50 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GKA50 is a potent glucokinase activator (EC50=33 nM at 5 mM glucose). GKA50 stimulates insulin release from mouse islets of Langerhans. GKA50 is a glucose-like activator of beta-cell metabolism in rodent and human islets and a Ca2+-dependent modulator of insulin secretion. GKA50 shows significant glucose lowering in high fat fed female rats[1][2][3][4].

体外研究
(In Vitro)

GKA50 (0.01-100 μM; 24 hours) enhances INS-1 cell proliferation with EC50values ranging from 1 to 2 μM[2].
GKA50 (1.2 μM+40 μM glucose; 2-4 days) treatment reduces apoptosis induced by chronic high glucose in INS-1 cells[2].
GKA50 activates human glucokinase enzymatic activity with an EC50 of 0.022 μM. GKA50 stimulates insulin secretion in the pancreatic insulinoma cell line, INS-1, with an EC50 of 0.065 μM. GKA50 reduces chronic-high-glucose-induced apoptosis via modulation of glucokinase and apoptotic protein BAD[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GKA50 相关抗体:

Cell Proliferation Assay[2]

Cell Line: INS-1 cells (starved overnight with 3 μM glucose)
Concentration: 0.01-100 μM
Incubation Time: 24 hours
Result: Stimulated cell proliferation in a dose-dependent manner, with EC50 values ranging from 1 to 2 μM.
体内研究
(In Vivo)

GKA50 (1-30 mg/kg; p.o.) gives significant glucose lowering in an oral glucose tolerance test[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: High-fat-fed obese female Zucker (fa/fa) rats[1]
Dosage: 1, 3, 10, 30 mg/kg
Administration: Oral administration
Result: Significant percentage glucose lowering.
分子量

464.51

Formula

C26H28N2O6
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 46 mg/mL (99.03 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1528 mL 10.7640 mL 21.5281 mL
5 mM 0.4306 mL 2.1528 mL 4.3056 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.57%

COA (265 KB) HNMR (282 KB) LCMS (267 KB)

产品使用指南 (1538 KB)
参考文献

GKA50 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1528 mL 10.7640 mL 21.5281 mL 53.8202 mL
5 mM 0.4306 mL 2.1528 mL 4.3056 mL 10.7640 mL
10 mM 0.2153 mL 1.0764 mL 2.1528 mL 5.3820 mL
15 mM 0.1435 mL 0.7176 mL 1.4352 mL 3.5880 mL
20 mM 0.1076 mL 0.5382 mL 1.0764 mL 2.6910 mL
25 mM 0.0861 mL 0.4306 mL 0.8611 mL 2.1528 mL
30 mM 0.0718 mL 0.3588 mL 0.7176 mL 1.7940 mL
40 mM 0.0538 mL 0.2691 mL 0.5382 mL 1.3455 mL
50 mM 0.0431 mL 0.2153 mL 0.4306 mL 1.0764 mL
60 mM 0.0359 mL 0.1794 mL 0.3588 mL 0.8970 mL
80 mM 0.0269 mL 0.1346 mL 0.2691 mL 0.6728 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GKA50851884-87-2GKA 50GKA-50GlucokinaseHexokinase IVHexokinase DglucoseinsulinMIN6highfatfedsecretionproliferationβ-cellsINS-1Inhibitorinhibitorinhibit

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